ID   POL_SIVV2               Reviewed;         100 AA.
AC   P12500;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Pol polyprotein;
DE   Flags: Fragment;
GN   Name=pol;
OS   Simian immunodeficiency virus agm.vervet (isolate AGM266) (SIV-agm.ver)
OS   (Simian immunodeficiency virus African green monkey vervet).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11728;
OH   NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2467010; DOI=10.1128/jvi.63.4.1800-1802.1989;
RA   Li Y., Naidu Y.M., Daniel M.D., Desrosiers R.C.;
RT   "Extensive genetic variability of simian immunodeficiency virus from
RT   African green monkeys.";
RL   J. Virol. 63:1800-1802(1989).
CC   -!- FUNCTION: During replicative cycle of retroviruses, the reverse-
CC       transcribed viral DNA is integrated into the host chromosome by the
CC       viral integrase enzyme. RNase H activity is associated with the reverse
CC       transcriptase.
CC   -!- MISCELLANEOUS: This is an African green monkey isolate.
CC   -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC       {ECO:0000305}.
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DR   EMBL; M22974; AAA47582.1; -; Genomic_RNA.
DR   SMR; P12500; -.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00075; RNase_H; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease; DNA integration; DNA recombination; Endonuclease;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Eukaryotic host translation shutoff by virus;
KW   Host gene expression shutoff by virus; Host-virus interaction; Hydrolase;
KW   Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Protease;
KW   RNA-directed DNA polymerase; Transferase.
FT   CHAIN           <1..>100
FT                   /note="Pol polyprotein"
FT                   /id="PRO_0000085308"
FT   DOMAIN          32..>100
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00408"
FT   NON_TER         1
FT   NON_TER         100
SQ   SEQUENCE   100 AA;  11075 MW;  DDA7003919874C1D CRC64;
     AGLLAGSWIP DWTFVSVPPL VTLWYTLTKE PIPGEDVYYV DGACNRNSRE GKAGYITQQG
     KQRVEKLENT TNQQAELTAI KMALEDSGPR VNIVTDSQYA