ID   POM34_CHATD             Reviewed;         326 AA.
AC   G0S7R3; G0ZGV6;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   24-JUN-2015, sequence version 2.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Nucleoporin POM34 {ECO:0000303|PubMed:21784248};
DE   AltName: Full=Nuclear pore protein POM34;
DE   AltName: Full=Pore membrane protein of 34 kDa;
GN   Name=POM34; ORFNames=CTHT_0028530;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC       NPC components, collectively referred to as nucleoporins (NUPs), can
CC       play the role of both NPC structural components and of docking or
CC       interaction partners for transiently associated nuclear transport
CC       factors. {ECO:0000250|UniProtKB:Q12445}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC). NPC constitutes
CC       the exclusive means of nucleocytoplasmic transport. NPCs allow the
CC       passive diffusion of ions and small molecules and the active, nuclear
CC       transport receptor-mediated bidirectional transport of macromolecules
CC       such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal
CC       subunits across the nuclear envelope. Due to its 8-fold rotational
CC       symmetry, all subunits are present with 8 copies or multiples thereof.
CC       {ECO:0000250|UniProtKB:Q12445, ECO:0000305|PubMed:21784248}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:Q12445}. Nucleus membrane
CC       {ECO:0000250|UniProtKB:Q12445}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q12445}. Note=Central core structure of the
CC       nuclear pore complex. {ECO:0000250|UniProtKB:Q12445}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EGS21013.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; GL988041; EGS21013.1; ALT_INIT; Genomic_DNA.
DR   EMBL; JF276301; AEL00694.1; -; Genomic_DNA.
DR   RefSeq; XP_006693309.1; XM_006693246.1.
DR   AlphaFoldDB; G0S7R3; -.
DR   TCDB; 1.I.1.1.2; the nuclear pore complex (npc) family.
DR   EnsemblFungi; EGS21013; EGS21013; CTHT_0028530.
DR   GeneID; 18256891; -.
DR   KEGG; cthr:CTHT_0028530; -.
DR   eggNOG; ENOG502S8U7; Eukaryota.
DR   HOGENOM; CLU_044363_0_0_1; -.
DR   OrthoDB; 1319461at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR012578; Nucl_pore_cmplx.
DR   PANTHER; PTHR28003; PTHR28003; 2.
DR   Pfam; PF08058; NPCC; 1.
PE   3: Inferred from homology;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..326
FT                   /note="Nucleoporin POM34"
FT                   /id="PRO_0000433189"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          134..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   326 AA;  34279 MW;  E2C521B788DBC07A CRC64;
     MSSTLSVAKA ASTPVKQITS AVGPVKESPG NWKHPRLAEI TRRQSRNIFG EKNVRQIVYN
     VAAIVLLEIF RVFASPSIPS QLILPSLRPY SLWIHAVFLV IPLTNIVIAL LPLFRPVDDL
     SDIPLTPAQR KLLGLPPSSK PATPNSVYST PPRYSRTPSL AGSPASIKSY TSSTLPTASS
     PTPGAAGIGA GSPAAPIYLS PSKFTTSTSS QQFSPSPSGA SPLLHRAISN TSTASGVSPY
     GSPNSPSKFG ASTNSTLAAS TISTSTFSVS TTSSIAHVLN NSRLRESVIE GVPATPTPVG
     KGASVKANSK WLYQRGRRTS SNNWVY