POMP_BOVIN
ID POMP_BOVIN Reviewed; 141 AA.
AC Q3SZV5;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Proteasome maturation protein;
DE AltName: Full=Proteassemblin;
GN Name=POMP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Molecular chaperone essential for the assembly of standard
CC proteasomes and immunoproteasomes. Degraded after completion of
CC proteasome maturation (By similarity). Mediates the association of 20S
CC preproteasome with the endoplasmic reticulum (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Constituent of preproteasomes, but not of mature 20S
CC proteasomes. Within the preproteasome, may directly interact with
CC PSMB1/beta6, PSMB4/beta7, PSMB5/beta5, PSMB6/beta1 and PSMB9/beta1i.
CC Interaction with PSMB8/beta5i is controversial. Forms tetramers (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC {ECO:0000250}. Microsome membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the POMP/UMP1 family. {ECO:0000305}.
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DR EMBL; BC102689; AAI02690.1; -; mRNA.
DR RefSeq; NP_001029548.1; NM_001034376.2.
DR AlphaFoldDB; Q3SZV5; -.
DR SMR; Q3SZV5; -.
DR STRING; 9913.ENSBTAP00000018626; -.
DR PaxDb; Q3SZV5; -.
DR PRIDE; Q3SZV5; -.
DR Ensembl; ENSBTAT00000018626; ENSBTAP00000018626; ENSBTAG00000014024.
DR GeneID; 510314; -.
DR KEGG; bta:510314; -.
DR CTD; 51371; -.
DR VEuPathDB; HostDB:ENSBTAG00000014024; -.
DR VGNC; VGNC:33157; POMP.
DR eggNOG; KOG3061; Eukaryota.
DR GeneTree; ENSGT00390000010734; -.
DR HOGENOM; CLU_100687_3_0_1; -.
DR InParanoid; Q3SZV5; -.
DR OMA; HHAMEVR; -.
DR OrthoDB; 1613776at2759; -.
DR TreeFam; TF323548; -.
DR Proteomes; UP000009136; Chromosome 12.
DR Bgee; ENSBTAG00000014024; Expressed in oocyte and 104 other tissues.
DR ExpressionAtlas; Q3SZV5; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043248; P:proteasome assembly; IBA:GO_Central.
DR InterPro; IPR008012; Ump1.
DR PANTHER; PTHR12828; PTHR12828; 1.
DR Pfam; PF05348; UMP1; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Cytoplasm; Endoplasmic reticulum; Isopeptide bond; Membrane;
KW Microsome; Nucleus; Reference proteome; Ubl conjugation.
FT CHAIN 1..141
FT /note="Proteasome maturation protein"
FT /id="PRO_0000247183"
FT CROSSLNK 39
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y244"
SQ SEQUENCE 141 AA; 15826 MW; 5CC673092FBAA7EF CRC64;
MNARGLGSQL KDSIPVTELS ASGPFESHDL LRKGFSCVKN ELLPSHPLEL SEKNFQLNQD
KMNFSTLRNI QGLFAPLKLQ MEFKAVQQVQ RLPFLPSSNL SLDILRGNDE TIGFEDILND
PSQSELMGEP HLMVEYKLGL L