POMP_MOUSE
ID POMP_MOUSE Reviewed; 141 AA.
AC Q9CQT5; Q9CXV8; Q9CZL7;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Proteasome maturation protein;
DE AltName: Full=Proteassemblin;
DE AltName: Full=Protein UMP1 homolog;
DE Short=mUMP1;
GN Name=Pomp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and DBA/2J;
RC TISSUE=Embryo, Embryonic head, Embryonic liver, and Lymphoma;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=10891394; DOI=10.1006/mcbr.2000.0213;
RA Griffin T.A., Slack J.P., McCluskey T.S., Monaco J.J., Colbert R.A.;
RT "Identification of proteassemblin, a mammalian homologue of the yeast
RT protein, Ump1p, that is required for normal proteasome assembly.";
RL Mol. Cell Biol. Res. Commun. 3:212-217(2000).
RN [4]
RP INDUCTION.
RX PubMed=10973495; DOI=10.1073/pnas.190268597;
RA Burri L., Hoeckendorff J., Boehm U., Klamp T., Dohmen R.J., Levy F.;
RT "Identification and characterization of a mammalian protein interacting
RT with 20S proteasome precursors.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:10348-10353(2000).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Molecular chaperone essential for the assembly of standard
CC proteasomes and immunoproteasomes. Degraded after completion of
CC proteasome maturation (By similarity). Mediates the association of 20S
CC preproteasome with the endoplasmic reticulum (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Constituent of preproteasomes, but not of mature 20S
CC proteasomes. Within the preproteasome, may directly interact with
CC PSMB1/beta6, PSMB4/beta7, PSMB5/beta5, PSMB6/beta1 and PSMB9/beta1i.
CC Interaction with PSMB8/beta5i is controversial. Forms tetramers (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC {ECO:0000250}. Microsome membrane {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10891394}.
CC -!- INDUCTION: By interferon gamma. {ECO:0000269|PubMed:10973495}.
CC -!- SIMILARITY: Belongs to the POMP/UMP1 family. {ECO:0000305}.
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DR EMBL; AK003439; BAB22791.1; -; mRNA.
DR EMBL; AK011115; BAB27410.1; -; mRNA.
DR EMBL; AK012455; BAB28250.1; -; mRNA.
DR EMBL; AK013934; BAB29067.1; -; mRNA.
DR EMBL; AK014296; BAB29252.1; -; mRNA.
DR EMBL; AK167958; BAE39956.1; -; mRNA.
DR EMBL; BC027016; AAH27016.1; -; mRNA.
DR CCDS; CCDS39402.1; -.
DR RefSeq; NP_079900.1; NM_025624.2.
DR AlphaFoldDB; Q9CQT5; -.
DR SMR; Q9CQT5; -.
DR BioGRID; 211543; 1.
DR STRING; 10090.ENSMUSP00000031654; -.
DR iPTMnet; Q9CQT5; -.
DR PhosphoSitePlus; Q9CQT5; -.
DR EPD; Q9CQT5; -.
DR MaxQB; Q9CQT5; -.
DR PaxDb; Q9CQT5; -.
DR PeptideAtlas; Q9CQT5; -.
DR PRIDE; Q9CQT5; -.
DR ProteomicsDB; 289363; -.
DR Antibodypedia; 7516; 126 antibodies from 26 providers.
DR DNASU; 66537; -.
DR Ensembl; ENSMUST00000031654; ENSMUSP00000031654; ENSMUSG00000029649.
DR GeneID; 66537; -.
DR KEGG; mmu:66537; -.
DR UCSC; uc009aoj.1; mouse.
DR CTD; 51371; -.
DR MGI; MGI:1913787; Pomp.
DR VEuPathDB; HostDB:ENSMUSG00000029649; -.
DR eggNOG; KOG3061; Eukaryota.
DR GeneTree; ENSGT00390000010734; -.
DR HOGENOM; CLU_100687_3_0_1; -.
DR InParanoid; Q9CQT5; -.
DR OMA; HHAMEVR; -.
DR OrthoDB; 1613776at2759; -.
DR PhylomeDB; Q9CQT5; -.
DR TreeFam; TF323548; -.
DR BioGRID-ORCS; 66537; 24 hits in 74 CRISPR screens.
DR ChiTaRS; Pomp; mouse.
DR PRO; PR:Q9CQT5; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CQT5; protein.
DR Bgee; ENSMUSG00000029649; Expressed in neural tube and 270 other tissues.
DR ExpressionAtlas; Q9CQT5; baseline and differential.
DR Genevisible; Q9CQT5; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0043248; P:proteasome assembly; ISO:MGI.
DR InterPro; IPR008012; Ump1.
DR PANTHER; PTHR12828; PTHR12828; 1.
DR Pfam; PF05348; UMP1; 1.
PE 1: Evidence at protein level;
KW Chaperone; Cytoplasm; Endoplasmic reticulum; Isopeptide bond; Membrane;
KW Microsome; Nucleus; Reference proteome; Ubl conjugation.
FT CHAIN 1..141
FT /note="Proteasome maturation protein"
FT /id="PRO_0000247185"
FT CROSSLNK 39
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y244"
FT CONFLICT 52
FT /note="E -> K (in Ref. 1; BAB29067)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="L -> Q (in Ref. 1; BAB28250)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 141 AA; 15766 MW; 5CDA8C2EB7E2D7DF CRC64;
MNARGLGSEL KDSIPVAELS ASGPFESHDL LRKGFSCVKN ELLPSHPLEL SEKNFQLNQD
KMNFSTLRNI QGLFAPLKLQ MEFKAVQQVH RLPFLPSSNL SLDILRGNDE TIGFEDILND
PSQSELMGEP HVMVEHKLGL L
