ID   POMP_PONAB              Reviewed;         141 AA.
AC   Q5R9L9;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Proteasome maturation protein;
DE   AltName: Full=Proteassemblin;
GN   Name=POMP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Molecular chaperone essential for the assembly of standard
CC       proteasomes and immunoproteasomes. Degraded after completion of
CC       proteasome maturation (By similarity). Mediates the association of 20S
CC       preproteasome with the endoplasmic reticulum (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Constituent of preproteasomes, but not of mature 20S
CC       proteasomes. Within the preproteasome, may directly interact with
CC       PSMB1/beta6, PSMB4/beta7, PSMB5/beta5, PSMB6/beta1 and PSMB9/beta1i.
CC       Interaction with PSMB8/beta5i is controversial. Forms tetramers (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Microsome membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the POMP/UMP1 family. {ECO:0000305}.
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DR   EMBL; CR859368; CAH91541.1; -; mRNA.
DR   RefSeq; NP_001125906.1; NM_001132434.1.
DR   AlphaFoldDB; Q5R9L9; -.
DR   SMR; Q5R9L9; -.
DR   STRING; 9601.ENSPPYP00000005974; -.
DR   Ensembl; ENSPPYT00000006209; ENSPPYP00000005974; ENSPPYG00000005247.
DR   GeneID; 100172839; -.
DR   KEGG; pon:100172839; -.
DR   CTD; 51371; -.
DR   eggNOG; KOG3061; Eukaryota.
DR   GeneTree; ENSGT00390000010734; -.
DR   HOGENOM; CLU_100687_3_0_1; -.
DR   InParanoid; Q5R9L9; -.
DR   OrthoDB; 1613776at2759; -.
DR   Proteomes; UP000001595; Chromosome 13.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0043248; P:proteasome assembly; IEA:Ensembl.
DR   InterPro; IPR008012; Ump1.
DR   PANTHER; PTHR12828; PTHR12828; 1.
DR   Pfam; PF05348; UMP1; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Cytoplasm; Endoplasmic reticulum; Isopeptide bond; Membrane;
KW   Microsome; Nucleus; Reference proteome; Ubl conjugation.
FT   CHAIN           1..141
FT                   /note="Proteasome maturation protein"
FT                   /id="PRO_0000247186"
FT   CROSSLNK        39
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y244"
SQ   SEQUENCE   141 AA;  15789 MW;  2136624D232EF1C7 CRC64;
     MNARGLGSEL KDSIPVTELS ASGPFESHDL LRKGFSCVKN ELLPSHPLEL SEKNFQLNQD
     KMNFSTLRNI QGLFAPLKLQ MEFKAVQQVQ RLPFLSSSNL SLDVLRGNDE TIGFEDILND
     PSQSEVMGEP HLMVEYKLGL L