PONF_DICDI
ID PONF_DICDI Reviewed; 171 AA.
AC Q54LH6;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Ponticulin-like protein F;
DE Flags: Precursor;
GN Name=ponF; ORFNames=DDB_G0286631;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP FUNCTION.
RX PubMed=18522444; DOI=10.1021/la800085n;
RA Barfoot R.J., Sheikh K.H., Johnson B.R., Colyer J., Miles R.E.,
RA Jeuken L.J., Bushby R.J., Evans S.D.;
RT "Minimal F-actin cytoskeletal system for planar supported phospholipid
RT bilayers.";
RL Langmuir 24:6827-6836(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- PTM: The GPI-like-anchor contains a phosphoceramide group, rather than
CC a phosphatidyl group. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ponticulin family. {ECO:0000305}.
CC -!- CAUTION: The Dictyosteliida are known to produce a
CC glycosylsphingolipidinositol anchor (GPI-like-anchor). It has not been
CC established whether Dictyosteliida make a glycosylphosphatidylinositol
CC anchor (GPI-anchor) also, and whether their GPI-like-anchor
CC modifications can be interconverted with GPI-anchor modifications in a
CC resculpting process. It has not been established that the GPI-like-
CC anchor modification in Dictyosteliida utilizes the same sequence motif.
CC {ECO:0000305}.
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DR EMBL; AAFI02000089; EAL64071.1; -; Genomic_DNA.
DR RefSeq; XP_637585.1; XM_632493.1.
DR AlphaFoldDB; Q54LH6; -.
DR STRING; 44689.DDB0237618; -.
DR PaxDb; Q54LH6; -.
DR EnsemblProtists; EAL64071; EAL64071; DDB_G0286631.
DR GeneID; 8625725; -.
DR KEGG; ddi:DDB_G0286631; -.
DR dictyBase; DDB_G0286631; ponF.
DR HOGENOM; CLU_1565767_0_0_1; -.
DR InParanoid; Q54LH6; -.
DR PhylomeDB; Q54LH6; -.
DR PRO; PR:Q54LH6; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..149
FT /note="Ponticulin-like protein F"
FT /id="PRO_0000312428"
FT PROPEP 150..171
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000312429"
FT LIPID 149
FT /note="GPI-like-anchor amidated glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 171 AA; 17322 MW; 19B77585B85FAA12 CRC64;
MKFIPALIIF VFTIFALTNS ETTYSGFKIT SADPKNPCSI SVPQTDVGTK CIDVCGQGNI
NIAAVSGETN KYDINGYQAT DQCKNSAGQQ TLTCGTPVTV GVFSIDCAPD AGATTAAVTT
AATTAAVTTA ATTAAVTTAS TTAAFTTTGT SSTIVIPFAL ILSLLLSVIT L
