PONL1_HUMAN
ID PONL1_HUMAN Reviewed; 512 AA.
AC Q6PEZ8; B7Z564; Q9H5G9;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Podocan-like protein 1;
DE Flags: Precursor;
GN Name=PODNL1; Synonyms=SLRR5B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Mammary gland, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:Q6P3Y9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6PEZ8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PEZ8-2; Sequence=VSP_043973, VSP_043974;
CC Name=3;
CC IsoId=Q6PEZ8-3; Sequence=VSP_043973;
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q6P3Y9}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class V subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15657.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR EMBL; AK027100; BAB15657.1; ALT_SEQ; mRNA.
DR EMBL; AK298489; BAH12800.1; -; mRNA.
DR EMBL; AC020916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471106; EAW84381.1; -; Genomic_DNA.
DR EMBL; BC057786; AAH57786.1; -; mRNA.
DR CCDS; CCDS54225.1; -. [Q6PEZ8-2]
DR CCDS; CCDS54226.1; -. [Q6PEZ8-3]
DR RefSeq; NP_001139726.1; NM_001146254.1. [Q6PEZ8-3]
DR RefSeq; NP_001139727.1; NM_001146255.1. [Q6PEZ8-2]
DR RefSeq; NP_079101.3; NM_024825.3.
DR AlphaFoldDB; Q6PEZ8; -.
DR SMR; Q6PEZ8; -.
DR BioGRID; 122968; 10.
DR STRING; 9606.ENSP00000345175; -.
DR GlyGen; Q6PEZ8; 1 site.
DR iPTMnet; Q6PEZ8; -.
DR PhosphoSitePlus; Q6PEZ8; -.
DR BioMuta; PODNL1; -.
DR DMDM; 296452863; -.
DR jPOST; Q6PEZ8; -.
DR MassIVE; Q6PEZ8; -.
DR PaxDb; Q6PEZ8; -.
DR PeptideAtlas; Q6PEZ8; -.
DR PRIDE; Q6PEZ8; -.
DR ProteomicsDB; 67090; -. [Q6PEZ8-1]
DR ProteomicsDB; 67091; -. [Q6PEZ8-2]
DR ProteomicsDB; 67092; -. [Q6PEZ8-3]
DR Antibodypedia; 50255; 75 antibodies from 18 providers.
DR DNASU; 79883; -.
DR Ensembl; ENST00000538371.6; ENSP00000442553.1; ENSG00000132000.14. [Q6PEZ8-3]
DR Ensembl; ENST00000538517.6; ENSP00000440080.1; ENSG00000132000.14. [Q6PEZ8-2]
DR Ensembl; ENST00000672131.1; ENSP00000500144.1; ENSG00000288195.1. [Q6PEZ8-2]
DR Ensembl; ENST00000672142.1; ENSP00000499876.1; ENSG00000288195.1. [Q6PEZ8-3]
DR GeneID; 79883; -.
DR KEGG; hsa:79883; -.
DR UCSC; uc002mxr.4; human. [Q6PEZ8-1]
DR CTD; 79883; -.
DR DisGeNET; 79883; -.
DR GeneCards; PODNL1; -.
DR HGNC; HGNC:26275; PODNL1.
DR HPA; ENSG00000132000; Low tissue specificity.
DR neXtProt; NX_Q6PEZ8; -.
DR OpenTargets; ENSG00000132000; -.
DR PharmGKB; PA162399855; -.
DR VEuPathDB; HostDB:ENSG00000132000; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000162059; -.
DR HOGENOM; CLU_000288_186_3_1; -.
DR InParanoid; Q6PEZ8; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q6PEZ8; -.
DR TreeFam; TF336377; -.
DR PathwayCommons; Q6PEZ8; -.
DR BioGRID-ORCS; 79883; 15 hits in 1071 CRISPR screens.
DR GenomeRNAi; 79883; -.
DR Pharos; Q6PEZ8; Tdark.
DR PRO; PR:Q6PEZ8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6PEZ8; protein.
DR Bgee; ENSG00000132000; Expressed in tibial nerve and 90 other tissues.
DR ExpressionAtlas; Q6PEZ8; baseline and differential.
DR Genevisible; Q6PEZ8; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 5.
DR SMART; SM00369; LRR_TYP; 13.
DR PROSITE; PS51450; LRR; 15.
PE 2: Evidence at transcript level;
KW Alternative splicing; Extracellular matrix; Glycoprotein;
KW Leucine-rich repeat; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..512
FT /note="Podocan-like protein 1"
FT /id="PRO_0000311187"
FT DOMAIN 37..74
FT /note="LRRNT"
FT REPEAT 75..96
FT /note="LRR 1"
FT REPEAT 99..119
FT /note="LRR 2"
FT REPEAT 125..146
FT /note="LRR 3"
FT REPEAT 147..167
FT /note="LRR 4"
FT REPEAT 170..193
FT /note="LRR 5"
FT REPEAT 196..216
FT /note="LRR 6"
FT REPEAT 217..238
FT /note="LRR 7"
FT REPEAT 241..261
FT /note="LRR 8"
FT REPEAT 267..288
FT /note="LRR 9"
FT REPEAT 289..309
FT /note="LRR 10"
FT REPEAT 312..332
FT /note="LRR 11"
FT REPEAT 338..359
FT /note="LRR 12"
FT REPEAT 360..380
FT /note="LRR 13"
FT REPEAT 383..396
FT /note="LRR 14"
FT REPEAT 409..430
FT /note="LRR 15"
FT REPEAT 431..451
FT /note="LRR 16"
FT REPEAT 454..474
FT /note="LRR 17"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..8
FT /note="MAESGLAM -> MGRPTQ (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043973"
FT VAR_SEQ 136..224
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043974"
FT VARIANT 44
FT /note="R -> W (in dbSNP:rs3745467)"
FT /id="VAR_037151"
FT CONFLICT 17
FT /note="L -> P (in Ref. 1; BAH12800)"
FT /evidence="ECO:0000305"
FT CONFLICT 43
FT /note="P -> L (in Ref. 3; AAH57786)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="P -> S (in Ref. 1; BAH12800)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 512 AA; 56539 MW; FF85F195D63869E7 CRC64;
MAESGLAMWP SLLLLLLLPG PPPVAGLEDA AFPHLGESLQ PLPRACPLRC SCPRVDTVDC
DGLDLRVFPD NITRAAQHLS LQNNQLQELP YNELSRLSGL RTLNLHNNLI SSEGLPDEAF
ESLTQLQHLC VAHNKLSVAP QFLPRSLRVA DLAANQVMEI FPLTFGEKPA LRSVYLHNNQ
LSNAGLPPDA FRGSEAIATL SLSNNQLSYL PPSLPPSLER LHLQNNLISK VPRGALSRQT
QLRELYLQHN QLTDSGLDAT TFSKLHSLEY LDLSHNQLTT VPAGLPRTLA ILHLGRNRIR
QVEAARLHGA RGLRYLLLQH NQLGSSGLPA GALRPLRGLH TLHLYGNGLD RVPPALPRRL
RALVLPHNHV AALGARDLVA TPGLTELNLA YNRLASARVH HRAFRRLRAL RSLDLAGNQL
TRLPMGLPTG LRTLQLQRNQ LRMLEPEPLA GLDQLRELSL AHNRLRVGDI GPGTWHELQA
LQVRHRLVSH TVPRAPPSPC LPCHVPNILV SW
