PONL1_MOUSE
ID PONL1_MOUSE Reviewed; 559 AA.
AC Q6P3Y9; A0A0R4J142; A1X874;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2016, sequence version 3.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Podocan-like protein 1;
DE Flags: Precursor;
GN Name=Podnl1 {ECO:0000312|MGI:MGI:2685352}; Synonyms=Gm506;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP GLYCOSYLATION.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:ABC17993.1};
RC TISSUE=Calvaria {ECO:0000312|EMBL:ABC17993.1};
RX PubMed=21672516; DOI=10.1016/j.bbrc.2011.05.150;
RA Mochida Y., Kaku M., Yoshida K., Katafuchi M., Atsawasuwan P., Yamauchi M.;
RT "Podocan-like protein: a novel small leucine-rich repeat matrix protein in
RT bone.";
RL Biochem. Biophys. Res. Commun. 410:333-338(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000269|PubMed:21672516}.
CC -!- TISSUE SPECIFICITY: Detected in bone where it is expressed in
CC osteoblasts and newly formed bone matrix (at protein level). Also
CC expressed weakly in osteoclasts (at protein level). Expressed strongly
CC in calvaria, lung and femur, and weakly in kidney.
CC {ECO:0000269|PubMed:21672516}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:21672516}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class V subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH63764.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; DQ303463; ABC17993.1; -; mRNA.
DR EMBL; AC159266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC063764; AAH63764.1; ALT_SEQ; mRNA.
DR CCDS; CCDS52615.1; -.
DR RefSeq; NP_001013402.2; NM_001013384.2.
DR AlphaFoldDB; Q6P3Y9; -.
DR SMR; Q6P3Y9; -.
DR BioGRID; 232659; 2.
DR STRING; 10090.ENSMUSP00000091073; -.
DR GlyGen; Q6P3Y9; 1 site.
DR iPTMnet; Q6P3Y9; -.
DR PhosphoSitePlus; Q6P3Y9; -.
DR PaxDb; Q6P3Y9; -.
DR PRIDE; Q6P3Y9; -.
DR Antibodypedia; 50255; 75 antibodies from 18 providers.
DR DNASU; 244550; -.
DR Ensembl; ENSMUST00000093380; ENSMUSP00000091073; ENSMUSG00000012889.
DR GeneID; 244550; -.
DR KEGG; mmu:244550; -.
DR UCSC; uc012gha.1; mouse.
DR CTD; 79883; -.
DR MGI; MGI:2685352; Podnl1.
DR VEuPathDB; HostDB:ENSMUSG00000012889; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000162059; -.
DR InParanoid; Q6P3Y9; -.
DR OMA; HLGRNCI; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q6P3Y9; -.
DR TreeFam; TF336377; -.
DR BioGRID-ORCS; 244550; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q6P3Y9; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q6P3Y9; protein.
DR Bgee; ENSMUSG00000012889; Expressed in ovary and 25 other tissues.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 5.
DR SMART; SM00369; LRR_TYP; 17.
DR PROSITE; PS51450; LRR; 15.
PE 1: Evidence at protein level;
KW Extracellular matrix; Glycoprotein; Leucine-rich repeat;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..559
FT /note="Podocan-like protein 1"
FT /id="PRO_0000311188"
FT REPEAT 66..89
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 90..115
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 117..139
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 140..160
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 161..186
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 188..208
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 209..231
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 233..257
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 258..281
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 283..302
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 303..328
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 329..352
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 354..373
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 374..399
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 400..423
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 425..444
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 445..470
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 471..494
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 496..515
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 517..541
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT CARBOHYD 64
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 189
FT /note="V -> A (in Ref. 3; AAH63764)"
FT /evidence="ECO:0000305"
FT CONFLICT 391
FT /note="H -> R (in Ref. 3; AAH63764)"
FT /evidence="ECO:0000305"
FT CONFLICT 454
FT /note="A -> T (in Ref. 3; AAH63764)"
FT /evidence="ECO:0000305"
FT CONFLICT 499
FT /note="Y -> H (in Ref. 3; AAH63764)"
FT /evidence="ECO:0000305"
FT CONFLICT 535
FT /note="R -> A (in Ref. 3; AAH63764)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 559 AA; 62519 MW; 498705005225AB94 CRC64;
MRPQELLLLL LMLKWSLAHT EDPAFPHLGD SSQPLPRPCP WRCSCPRDDT VDCAGLDLRI
FPDNITRAAR HLSLQNNQLR ELPYNELSRL SGLRTLDLHS NLITSEGLPD EAFESLNQLE
NFYVAHNKLS VAPQFLPRSL RVADLAANEV VEIFPLTFGE KPALRSVYLH NNRLRNTGLP
PNTFHGSEVI TTLSLSSNQL SYLPPSLPAS LERLHLQNNL ISKVPRGALS LQTHLRELYL
QHNQLTDSGL DATTFSKLSS LEYLDLSHNQ LATVPEGLPG TLTILHLGRN CIRHVEAVRL
HKARGLRYLL LQHNKLGASA LPKGTLRPLR ALHTLHLYGN KLERVPPALP RHLQALVMPH
NHVAALGARD LVSARALAEL NLAYNSLASA HVHPSAFRRL RALRSLDLAG NQLTRLPEGL
PASLRSLRLQ RNQLRTLEPE QLAGLNKLRE LNLAHNRLRV GDIGPGTWHE LQALKVLDLS
HNELSFVPPD LPEALEELYL QANRISHVGP EAFLSTPHLR ALFLRANRLH MTSIRAEALQ
GLTHLRVVDT AENPEQVLV
