POP5_ARATH
ID POP5_ARATH Reviewed; 151 AA.
AC Q6AWV1; O23021;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Probable ribonuclease P/MRP protein subunit POP5 {ECO:0000250|UniProtKB:Q969H6};
DE AltName: Full=Protein EMBRYO DEFECTIVE 1687;
GN Name=EMB1687; OrderedLocusNames=At1g04635 {ECO:0000312|Araport:AT1G04635};
GN ORFNames=T1G11.24 {ECO:0000312|EMBL:AAB80636.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION [LARGE SCALE ANALYSIS], AND DISRUPTION PHENOTYPE [LARGE SCALE
RP ANALYSIS].
RC STRAIN=cv. Columbia;
RX PubMed=15266054; DOI=10.1104/pp.104.045179;
RA Tzafrir I., Pena-Muralla R., Dickerman A., Berg M., Rogers R., Hutchens S.,
RA Sweeney T.C., McElver J., Aux G., Patton D., Meinke D.;
RT "Identification of genes required for embryo development in Arabidopsis.";
RL Plant Physiol. 135:1206-1220(2004).
RN [5]
RP INTERACTION WITH GAF1/RPP30.
RX PubMed=22509260; DOI=10.1371/journal.pone.0033595;
RA Wang S.-Q., Shi D.-Q., Long Y.-P., Liu J., Yang W.-C.;
RT "GAMETOPHYTE DEFECTIVE 1, a putative subunit of RNases P/MRP, is essential
RT for female gametogenesis and male competence in Arabidopsis.";
RL PLoS ONE 7:E33595-E33595(2012).
CC -!- FUNCTION: Essential protein required during embryogenesis
CC (PubMed:15266054). Component of ribonuclease P, a protein complex that
CC generates mature tRNA molecules by cleaving their 5'-ends (By
CC similarity). Also a component of RNase MRP (By similarity).
CC {ECO:0000250|UniProtKB:Q969H6, ECO:0000269|PubMed:15266054}.
CC -!- SUBUNIT: Component of nuclear RNase P and RNase MRP ribonucleoproteins
CC (By similarity). Interacts with GAF1/RPP30 (PubMed:22509260).
CC {ECO:0000250|UniProtKB:Q969H6, ECO:0000269|PubMed:22509260}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q969H6}.
CC -!- DISRUPTION PHENOTYPE: Defective embryo arrested at the globular stage.
CC {ECO:0000269|PubMed:15266054}.
CC -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC component 2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB80636.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g04640 has been split into 2 genes: At1g04635 and At1g04640.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Seed defective Arabidopsis mutants;
CC URL="http://seedgenes.org/MutantList";
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DR EMBL; AC002376; AAB80636.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27725.1; -; Genomic_DNA.
DR EMBL; BT015147; AAT85743.1; -; mRNA.
DR EMBL; BT015896; AAU95432.1; -; mRNA.
DR PIR; B86179; B86179.
DR RefSeq; NP_683274.1; NM_148433.3.
DR AlphaFoldDB; Q6AWV1; -.
DR SMR; Q6AWV1; -.
DR BioGRID; 24695; 1.
DR STRING; 3702.AT1G04635.1; -.
DR PaxDb; Q6AWV1; -.
DR PRIDE; Q6AWV1; -.
DR ProteomicsDB; 251074; -.
DR DNASU; 839460; -.
DR EnsemblPlants; AT1G04635.1; AT1G04635.1; AT1G04635.
DR GeneID; 839460; -.
DR Gramene; AT1G04635.1; AT1G04635.1; AT1G04635.
DR KEGG; ath:AT1G04635; -.
DR Araport; AT1G04635; -.
DR TAIR; locus:504956160; AT1G04635.
DR eggNOG; KOG4639; Eukaryota.
DR HOGENOM; CLU_086710_0_1_1; -.
DR InParanoid; Q6AWV1; -.
DR OMA; MQNYLDK; -.
DR OrthoDB; 1492689at2759; -.
DR PhylomeDB; Q6AWV1; -.
DR PRO; PR:Q6AWV1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6AWV1; baseline and differential.
DR GO; GO:0005655; C:nucleolar ribonuclease P complex; IBA:GO_Central.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0000172; C:ribonuclease MRP complex; IBA:GO_Central.
DR GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-EC.
DR GO; GO:0033204; F:ribonuclease P RNA binding; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR GO; GO:0001682; P:tRNA 5'-leader removal; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IBA:GO_Central.
DR Gene3D; 3.30.70.3250; -; 1.
DR InterPro; IPR002759; Pop5/Rpp14/Rnp2-like.
DR InterPro; IPR016819; RNase_P/MRP_POP5.
DR InterPro; IPR038085; Rnp2-like_sf.
DR Pfam; PF01900; RNase_P_Rpp14; 1.
DR PIRSF; PIRSF023803; Ribonuclease_P_prd; 1.
DR SUPFAM; SSF160350; SSF160350; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; tRNA processing.
FT CHAIN 1..151
FT /note="Probable ribonuclease P/MRP protein subunit POP5"
FT /id="PRO_0000140013"
SQ SEQUENCE 151 AA; 17017 MW; 6EC227EF0C0116E9 CRC64;
MVGFKNRYML MEVFLDPDKD LLGEGTPIIL TQFNLSKAIK DSILVNFGEC GLGSSLGSFQ
VKYVNPITKL CIVRSSREEH RQVWLAITLV KSIGNCPVIL NLLDISGCIR ACRDTALKCD
KEKFEQCSKS LSEEEIRQMN TSLEKIKLLE N
