ID   POP5_BOVIN              Reviewed;         170 AA.
AC   Q1JQ92;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Ribonuclease P/MRP protein subunit POP5;
GN   Name=POP5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of ribonuclease P, a protein complex that generates
CC       mature tRNA molecules by cleaving their 5'-ends. Also a component of
CC       the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
CC       {ECO:0000250|UniProtKB:Q969H6}.
CC   -!- SUBUNIT: Component of nuclear RNase P and RNase MRP ribonucleoproteins.
CC       RNase P consists of a catalytic RNA moiety and 10 different protein
CC       chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and
CC       RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the
CC       'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the
CC       'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist'
CC       subcomplex. All subunits of the RNase P complex interact with the
CC       catalytic RNA. Several subunits of RNase P are also part of the RNase
CC       MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8
CC       protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly
CC       also POP4 and POP5. {ECO:0000250|UniProtKB:Q969H6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q969H6}.
CC   -!- MISCELLANEOUS: The last C-terminal 19 amino acids are not required for
CC       complex association and RNase activity.
CC   -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC       component 2 family. {ECO:0000305}.
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DR   EMBL; BC116153; AAI16154.1; -; mRNA.
DR   RefSeq; NP_001068780.1; NM_001075312.2.
DR   AlphaFoldDB; Q1JQ92; -.
DR   SMR; Q1JQ92; -.
DR   STRING; 9913.ENSBTAP00000007083; -.
DR   PaxDb; Q1JQ92; -.
DR   GeneID; 507410; -.
DR   KEGG; bta:507410; -.
DR   CTD; 51367; -.
DR   eggNOG; KOG4639; Eukaryota.
DR   InParanoid; Q1JQ92; -.
DR   OrthoDB; 1492689at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0030681; C:multimeric ribonuclease P complex; ISS:UniProtKB.
DR   GO; GO:0005655; C:nucleolar ribonuclease P complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0000172; C:ribonuclease MRP complex; IBA:GO_Central.
DR   GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-EC.
DR   GO; GO:0033204; F:ribonuclease P RNA binding; ISS:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   GO; GO:0001682; P:tRNA 5'-leader removal; ISS:UniProtKB.
DR   GO; GO:0008033; P:tRNA processing; IBA:GO_Central.
DR   Gene3D; 3.30.70.3250; -; 1.
DR   InterPro; IPR002759; Pop5/Rpp14/Rnp2-like.
DR   InterPro; IPR016819; RNase_P/MRP_POP5.
DR   InterPro; IPR038085; Rnp2-like_sf.
DR   Pfam; PF01900; RNase_P_Rpp14; 1.
DR   PIRSF; PIRSF023803; Ribonuclease_P_prd; 1.
DR   SUPFAM; SSF160350; SSF160350; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; rRNA processing;
KW   tRNA processing.
FT   CHAIN           1..170
FT                   /note="Ribonuclease P/MRP protein subunit POP5"
FT                   /id="PRO_0000327379"
FT   REGION          149..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         158
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DB28"
FT   MOD_RES         160
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DB28"
SQ   SEQUENCE   170 AA;  19351 MW;  712668C4F7745A8C CRC64;
     MVRFKHRYLL CEVVSDDPRC RLTLEDRVLG TLVRDTIARV HGTFGAAACS IGFAVRYLNA
     YTGIVLLRCR KEFYRLVWSA LPFITSLENK GHRYPCFLNT LHVGGTIRTC QKFLIQYNRR
     QLLILLQNCT DEGEREAIQK SVTKSCLLEE ESAGEELSDS GGEETAEPME