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POP5_DANRE
ID   POP5_DANRE              Reviewed;         169 AA.
AC   Q5BJI6;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Ribonuclease P/MRP protein subunit POP5;
GN   Name=pop5; ORFNames=zgc:110616;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of ribonuclease P, a protein complex that generates
CC       mature tRNA molecules by cleaving their 5'-ends. Also a component of
CC       the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
CC       {ECO:0000250|UniProtKB:Q969H6}.
CC   -!- SUBUNIT: Component of nuclear RNase P and RNase MRP ribonucleoproteins.
CC       RNase P consists of a catalytic RNA moiety and 10 different protein
CC       chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and
CC       RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the
CC       'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the
CC       'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist'
CC       subcomplex. All subunits of the RNase P complex interact with the
CC       catalytic RNA. Several subunits of RNase P are also part of the RNase
CC       MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8
CC       protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly
CC       also POP4 and POP5. {ECO:0000250|UniProtKB:Q969H6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q969H6}.
CC   -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC       component 2 family. {ECO:0000305}.
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DR   EMBL; BC091467; AAH91467.1; -; mRNA.
DR   RefSeq; NP_001013566.1; NM_001013548.1.
DR   AlphaFoldDB; Q5BJI6; -.
DR   SMR; Q5BJI6; -.
DR   STRING; 7955.ENSDARP00000069973; -.
DR   PaxDb; Q5BJI6; -.
DR   Ensembl; ENSDART00000075491; ENSDARP00000069973; ENSDARG00000053452.
DR   GeneID; 541421; -.
DR   KEGG; dre:541421; -.
DR   CTD; 51367; -.
DR   ZFIN; ZDB-GENE-050320-123; pop5.
DR   eggNOG; KOG4639; Eukaryota.
DR   GeneTree; ENSGT00390000012331; -.
DR   HOGENOM; CLU_086710_2_0_1; -.
DR   InParanoid; Q5BJI6; -.
DR   OMA; FLDRAMG; -.
DR   OrthoDB; 1492689at2759; -.
DR   PhylomeDB; Q5BJI6; -.
DR   TreeFam; TF317496; -.
DR   PRO; PR:Q5BJI6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000053452; Expressed in mature ovarian follicle and 25 other tissues.
DR   GO; GO:0030681; C:multimeric ribonuclease P complex; ISS:UniProtKB.
DR   GO; GO:0005655; C:nucleolar ribonuclease P complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0000172; C:ribonuclease MRP complex; IBA:GO_Central.
DR   GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-EC.
DR   GO; GO:0033204; F:ribonuclease P RNA binding; ISS:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   GO; GO:0001682; P:tRNA 5'-leader removal; ISS:UniProtKB.
DR   GO; GO:0008033; P:tRNA processing; IBA:GO_Central.
DR   Gene3D; 3.30.70.3250; -; 1.
DR   InterPro; IPR002759; Pop5/Rpp14/Rnp2-like.
DR   InterPro; IPR016819; RNase_P/MRP_POP5.
DR   InterPro; IPR038085; Rnp2-like_sf.
DR   Pfam; PF01900; RNase_P_Rpp14; 1.
DR   PIRSF; PIRSF023803; Ribonuclease_P_prd; 1.
DR   SUPFAM; SSF160350; SSF160350; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; rRNA processing; tRNA processing.
FT   CHAIN           1..169
FT                   /note="Ribonuclease P/MRP protein subunit POP5"
FT                   /id="PRO_0000239009"
SQ   SEQUENCE   169 AA;  19306 MW;  E0C78539E13B9880 CRC64;
     MVRFKSRYLL CELCVSEPSS LHLFEDKVVY QALRGAVNRA HGDYGAAIFN ITLGVLVKYL
     NAHTGVVLIR CRKAHYRLVW SSLPFITFLE NRGQKVRCFF NCIHVGGTIR TSQKFLIKYN
     RQQLQRMLLD CKTDAEKQDV RKAILSCSLN LIKGEETDGS DDDGDEEDT
 
 
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