ID   POP5_DICDI              Reviewed;         171 AA.
AC   Q54EP3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Probable ribonuclease P/MRP protein subunit POP5;
DE            EC=3.1.26.5;
GN   Name=pop5; ORFNames=DDB_G0291662;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of ribonuclease P, a protein complex that generates
CC       mature tRNA molecules by cleaving their 5'-ends. Also a component of
CC       RNase MRP (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC         from tRNA precursor.; EC=3.1.26.5;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC       component 2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000177; EAL61815.1; -; Genomic_DNA.
DR   RefSeq; XP_635197.1; XM_630105.1.
DR   AlphaFoldDB; Q54EP3; -.
DR   SMR; Q54EP3; -.
DR   STRING; 44689.DDB0237627; -.
DR   PaxDb; Q54EP3; -.
DR   EnsemblProtists; EAL61815; EAL61815; DDB_G0291662.
DR   GeneID; 8628142; -.
DR   KEGG; ddi:DDB_G0291662; -.
DR   dictyBase; DDB_G0291662; pop5.
DR   eggNOG; KOG4639; Eukaryota.
DR   HOGENOM; CLU_086710_3_0_1; -.
DR   InParanoid; Q54EP3; -.
DR   OMA; MQNYLDK; -.
DR   PhylomeDB; Q54EP3; -.
DR   PRO; PR:Q54EP3; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005655; C:nucleolar ribonuclease P complex; ISS:dictyBase.
DR   GO; GO:0000172; C:ribonuclease MRP complex; ISS:dictyBase.
DR   GO; GO:0004526; F:ribonuclease P activity; ISS:dictyBase.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   GO; GO:0001682; P:tRNA 5'-leader removal; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IBA:GO_Central.
DR   Gene3D; 3.30.70.3250; -; 1.
DR   InterPro; IPR002759; Pop5/Rpp14/Rnp2-like.
DR   InterPro; IPR038085; Rnp2-like_sf.
DR   Pfam; PF01900; RNase_P_Rpp14; 1.
DR   SUPFAM; SSF160350; SSF160350; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Nucleus; Reference proteome; tRNA processing.
FT   CHAIN           1..171
FT                   /note="Probable ribonuclease P/MRP protein subunit POP5"
FT                   /id="PRO_0000327380"
FT   REGION          131..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..153
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   171 AA;  19916 MW;  0225413D5ACE16C5 CRC64;
     MVRLKNRYLM TEVIWHDNEK STQLSDSWLF QFISNEVKEK LGELTYEAFK KTLKIIYVNP
     DTNIFIIRVS FEYYKSLWTA LTLITSYYGV PIYFRMVHVG GSIRLCQKAA IKIFGKQISV
     YDKNKILRNE KGETIDNNNN KNEEPSIKMD SDDDENGGGD DGEDNDSEMK D