POP7_DROME
ID POP7_DROME Reviewed; 167 AA.
AC Q2MGL3; C0PUX7;
DT 13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Ribonuclease P protein subunit p20 {ECO:0000250|UniProtKB:O75817};
DE Short=RNaseP protein p20 {ECO:0000250|UniProtKB:O75817};
GN Name=Rpp20 {ECO:0000312|FlyBase:FBgn0066304};
GN ORFNames=CG33931 {ECO:0000312|FlyBase:FBgn0066304};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAZ52504.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|EMBL:AAZ52504.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:ACN62436.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP INTERACTION WITH SMN.
RX PubMed=14715275; DOI=10.1016/j.bbrc.2003.12.084;
RA Hua Y., Zhou J.;
RT "Rpp20 interacts with SMN and is re-distributed into SMN granules in
RT response to stress.";
RL Biochem. Biophys. Res. Commun. 314:268-276(2004).
CC -!- FUNCTION: Component of ribonuclease P, a protein complex that generates
CC mature tRNA molecules by cleaving their 5'-ends. Also a component of
CC RNase MRP complex, which cleaves pre-rRNA sequences (By similarity).
CC {ECO:0000250|UniProtKB:O75817}.
CC -!- SUBUNIT: Interacts with Smn. {ECO:0000269|PubMed:14715275}.
CC -!- INTERACTION:
CC Q2MGL3; Q9VV74: Smn; NbExp=3; IntAct=EBI-1151669, EBI-185315;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:O75817}. Cytoplasm
CC {ECO:0000250|UniProtKB:O75817}. Cytoplasmic granule
CC {ECO:0000250|UniProtKB:O75817}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACN62436.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014298; AAZ52504.1; -; Genomic_DNA.
DR EMBL; BT072833; ACN62436.1; ALT_INIT; mRNA.
DR RefSeq; NP_001027078.1; NM_001031907.2.
DR RefSeq; NP_001285462.1; NM_001298533.1.
DR AlphaFoldDB; Q2MGL3; -.
DR SMR; Q2MGL3; -.
DR BioGRID; 533604; 4.
DR IntAct; Q2MGL3; 3.
DR STRING; 7227.FBpp0099986; -.
DR PaxDb; Q2MGL3; -.
DR DNASU; 3772007; -.
DR EnsemblMetazoa; FBtr0091935; FBpp0099986; FBgn0066304.
DR EnsemblMetazoa; FBtr0346040; FBpp0311904; FBgn0066304.
DR GeneID; 3772007; -.
DR KEGG; dme:Dmel_CG33931; -.
DR UCSC; CG33931-RA; d. melanogaster.
DR CTD; 3772007; -.
DR FlyBase; FBgn0066304; Rpp20.
DR VEuPathDB; VectorBase:FBgn0066304; -.
DR eggNOG; KOG3631; Eukaryota.
DR HOGENOM; CLU_130587_1_0_1; -.
DR InParanoid; Q2MGL3; -.
DR OMA; HIYITRK; -.
DR PhylomeDB; Q2MGL3; -.
DR SignaLink; Q2MGL3; -.
DR BioGRID-ORCS; 3772007; 1 hit in 1 CRISPR screen.
DR ChiTaRS; Rpp20; fly.
DR GenomeRNAi; 3772007; -.
DR PRO; PR:Q2MGL3; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0066304; Expressed in ovary and 11 other tissues.
DR Genevisible; Q2MGL3; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0030681; C:multimeric ribonuclease P complex; ISS:FlyBase.
DR GO; GO:0005655; C:nucleolar ribonuclease P complex; ISS:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000172; C:ribonuclease MRP complex; ISS:FlyBase.
DR GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-EC.
DR GO; GO:0033204; F:ribonuclease P RNA binding; ISS:FlyBase.
DR GO; GO:0090502; P:RNA phosphodiester bond hydrolysis, endonucleolytic; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:FlyBase.
DR GO; GO:0001682; P:tRNA 5'-leader removal; ISS:FlyBase.
DR GO; GO:0008033; P:tRNA processing; ISS:FlyBase.
DR Gene3D; 3.30.110.20; -; 1.
DR InterPro; IPR036882; Alba-like_dom_sf.
DR InterPro; IPR002775; DNA/RNA-bd_Alba-like.
DR InterPro; IPR014612; Pop7/Rpp20.
DR PANTHER; PTHR15314; PTHR15314; 1.
DR Pfam; PF01918; Alba; 1.
DR SUPFAM; SSF82704; SSF82704; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; tRNA processing.
FT CHAIN 1..167
FT /note="Ribonuclease P protein subunit p20"
FT /id="PRO_0000424383"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 167 AA; 18876 MW; D7A2ECA5688DCA3E CRC64;
MMGSNYPEHG TKPRSAKYHK QQNHRVVRKQ PPRPAVSDRH NIYITSKTDF KAQQRRCEEL
INSGAHEIFL HCMGFSVTRG LNIALRLVQN SDGALSYAIN TSTVQLVDEL HPLCDAEDIT
FRQRNNSALH IKILNNSLFD IAVPQPSQSQ TQAQSLGQFR GKAKARQ
