ID   POPD3_CHICK             Reviewed;         305 AA.
AC   Q9DG25;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Popeye domain-containing protein 3;
DE            Short=Popeye protein 3;
GN   Name=POPDC3; Synonyms=POP3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, ALTERNATIVE SPLICING,
RP   DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC   STRAIN=White leghorn;
RX   PubMed=10882522; DOI=10.1006/dbio.2000.9751;
RA   Andree B., Hillemann T., Kessler-Icekson G., Schmitt-John T., Jockusch H.,
RA   Arnold H.-H., Brand T.;
RT   "Isolation and characterization of the novel popeye gene family expressed
RT   in skeletal muscle and heart.";
RL   Dev. Biol. 223:371-382(2000).
CC   -!- FUNCTION: May play a role in the maintenance of heart function
CC       mediated, at least in part, through cAMP-binding. May play a role in
CC       the regulation of KCNK2-mediated current amplitude (By similarity).
CC       {ECO:0000250|UniProtKB:Q9ES81, ECO:0000250|UniProtKB:Q9HBV1,
CC       ECO:0000269|PubMed:10882522}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=POP3A;
CC         IsoId=Q9DG25-1; Sequence=Displayed;
CC       Name=2; Synonyms=POP3B;
CC         IsoId=Q9DG25-2; Sequence=Not described;
CC   -!- TISSUE SPECIFICITY: Expressed first preferentially in atrium and later
CC       also in the subepicardial compact layer of the ventricles.
CC       {ECO:0000269|PubMed:10882522}.
CC   -!- DEVELOPMENTAL STAGE: Expression was first detected at HH stage 10 and
CC       was initially expressed throughout the heart. With heart looping at HH
CC       stage 11, expression was restricted to the atrial compartment and
CC       absent from the presumptive ventricular segments. The atrial-specific
CC       expression was still observed at stage 17. During HH stages 17-24,
CC       increased expression in the subepicardial compact layer was seen. At HH
CC       stage 30, expression was seen intensely in the whole myocardium with
CC       the exception of the outflow tract. {ECO:0000269|PubMed:10882522}.
CC   -!- SIMILARITY: Belongs to the popeye family. {ECO:0000305}.
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DR   EMBL; AF204170; AAG23403.1; -; mRNA.
DR   RefSeq; NP_990028.1; NM_204697.2. [Q9DG25-1]
DR   AlphaFoldDB; Q9DG25; -.
DR   SMR; Q9DG25; -.
DR   STRING; 9031.ENSGALP00000036460; -.
DR   GeneID; 395434; -.
DR   KEGG; gga:395434; -.
DR   CTD; 64208; -.
DR   VEuPathDB; HostDB:geneid_395434; -.
DR   eggNOG; ENOG502QWBZ; Eukaryota.
DR   HOGENOM; CLU_048494_2_1_1; -.
DR   OrthoDB; 1369469at2759; -.
DR   PRO; PR:Q9DG25; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0030552; F:cAMP binding; IBA:GO_Central.
DR   GO; GO:0007507; P:heart development; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0007519; P:skeletal muscle tissue development; IBA:GO_Central.
DR   GO; GO:0051146; P:striated muscle cell differentiation; IBA:GO_Central.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR006916; Popeye_prot.
DR   PANTHER; PTHR12101; PTHR12101; 1.
DR   Pfam; PF04831; Popeye; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; cAMP; cAMP-binding; Glycoprotein; Membrane;
KW   Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..305
FT                   /note="Popeye domain-containing protein 3"
FT                   /id="PRO_0000046797"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          273..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        298
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   305 AA;  34976 MW;  D5443EEBCAF7EACB CRC64;
     MGENASFWES LIYAHPTCVT WKQEAEGSIY HLASILFVVG FMGGSGFSGL LYVFSLLGLG
     FLCSSVWAWL DVCAADIFSW NFILFAICFV QFIYVTYQVR SVSFDKEFQE LYSALFQPLG
     ISLTVYRKIV LCCDAEVITL EKEHCYAMQG KTPIDKLSLL VSGRIRVTVD GEFLHYIFPL
     QFLDSPEWDS LRPTEEGIFQ VTLTAETDCR YVAWRRKKLY LLFAKHRFIS RLFSILIGSD
     IAEKLYALND RVHVGKGFRY DIRLPNFYHT SLPETPPVPP PRRLQRRSSG RPRPGVPNCS
     SPRKQ