POPD3_MOUSE
ID POPD3_MOUSE Reviewed; 291 AA.
AC Q9ES81; Q1RME0;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Popeye domain-containing protein 3;
DE Short=Popeye protein 3;
GN Name=Popdc3; Synonyms=Pop3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=10882522; DOI=10.1006/dbio.2000.9751;
RA Andree B., Hillemann T., Kessler-Icekson G., Schmitt-John T., Jockusch H.,
RA Arnold H.-H., Brand T.;
RT "Isolation and characterization of the novel popeye gene family expressed
RT in skeletal muscle and heart.";
RL Dev. Biol. 223:371-382(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND CAMP-BINDING.
RX PubMed=22354168; DOI=10.1172/jci59410;
RA Froese A., Breher S.S., Waldeyer C., Schindler R.F., Nikolaev V.O.,
RA Rinne S., Wischmeyer E., Schlueter J., Becher J., Simrick S., Vauti F.,
RA Kuhtz J., Meister P., Kreissl S., Torlopp A., Liebig S.K., Laakmann S.,
RA Mueller T.D., Neumann J., Stieber J., Ludwig A., Maier S.K., Decher N.,
RA Arnold H.H., Kirchhof P., Fabritz L., Brand T.;
RT "Popeye domain containing proteins are essential for stress-mediated
RT modulation of cardiac pacemaking in mice.";
RL J. Clin. Invest. 122:1119-1130(2012).
CC -!- FUNCTION: May play a role in the maintenance of heart function
CC mediated, at least in part, through cAMP-binding. May play a role in
CC the regulation of KCNK2-mediated current amplitude (By similarity).
CC {ECO:0000250|UniProtKB:Q9HBV1, ECO:0000269|PubMed:10882522,
CC ECO:0000269|PubMed:22354168}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in cardiac and skeletal muscle.
CC {ECO:0000269|PubMed:10882522}.
CC -!- SIMILARITY: Belongs to the popeye family. {ECO:0000305}.
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DR EMBL; AF204176; AAG23409.1; -; mRNA.
DR EMBL; AK052325; BAC34938.1; -; mRNA.
DR EMBL; BC114993; AAI14994.1; -; mRNA.
DR CCDS; CCDS23827.1; -.
DR RefSeq; NP_077248.1; NM_024286.1.
DR AlphaFoldDB; Q9ES81; -.
DR STRING; 10090.ENSMUSP00000019994; -.
DR GlyGen; Q9ES81; 1 site.
DR iPTMnet; Q9ES81; -.
DR PhosphoSitePlus; Q9ES81; -.
DR PaxDb; Q9ES81; -.
DR PRIDE; Q9ES81; -.
DR ProteomicsDB; 289719; -.
DR Antibodypedia; 32110; 135 antibodies from 22 providers.
DR DNASU; 78977; -.
DR Ensembl; ENSMUST00000019994; ENSMUSP00000019994; ENSMUSG00000019848.
DR GeneID; 78977; -.
DR KEGG; mmu:78977; -.
DR UCSC; uc007ezy.1; mouse.
DR CTD; 64208; -.
DR MGI; MGI:1930153; Popdc3.
DR VEuPathDB; HostDB:ENSMUSG00000019848; -.
DR eggNOG; ENOG502QWBZ; Eukaryota.
DR GeneTree; ENSGT00390000002563; -.
DR HOGENOM; CLU_048494_2_1_1; -.
DR InParanoid; Q9ES81; -.
DR OMA; QGFRYDI; -.
DR OrthoDB; 1369469at2759; -.
DR PhylomeDB; Q9ES81; -.
DR TreeFam; TF326644; -.
DR BioGRID-ORCS; 78977; 1 hit in 75 CRISPR screens.
DR PRO; PR:Q9ES81; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9ES81; protein.
DR Bgee; ENSMUSG00000019848; Expressed in triceps brachii and 118 other tissues.
DR ExpressionAtlas; Q9ES81; baseline and differential.
DR Genevisible; Q9ES81; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR GO; GO:0030552; F:cAMP binding; IDA:UniProtKB.
DR GO; GO:0007507; P:heart development; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IGI:MGI.
DR GO; GO:0007519; P:skeletal muscle tissue development; IBA:GO_Central.
DR GO; GO:0051146; P:striated muscle cell differentiation; IBA:GO_Central.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR006916; Popeye_prot.
DR PANTHER; PTHR12101; PTHR12101; 1.
DR Pfam; PF04831; Popeye; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
PE 1: Evidence at protein level;
KW cAMP; cAMP-binding; Glycoprotein; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..291
FT /note="Popeye domain-containing protein 3"
FT /id="PRO_0000046796"
FT TRANSMEM 27..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 291 AA; 33612 MW; 8AC6BFE107AEEE12 CRC64;
MEKNSSLWKS LVTEHPLCTT WKQEAEGAIY HLASILFVVG FMGGSGFFGL LYVFSLLGLG
FLSSAVWAWV DICAADIFSW NFVLFVICFM QFVHIAYQVH SITFARDFHV LYSSLFKPLG
IPLPVFRTIA LSSEVVSLEK EHCYAMQGKT SIDRLSVLIS GRIRVTVDGE FLHYISPFQF
LDSPEWDSLR PTEEGIFQVT LTADTDCRYV SWRRKKLYLL FAQHRYISRL FSVLIGSDIA
DKLYALNDRV YIGKKHHYDI RLPNYYHMST PDLSRSPLTE QFRNSRQHCN K
