ID   POPL1_CAEEL             Reviewed;         752 AA.
AC   Q11188;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Ribonucleases P/MRP protein subunit popl-1 {ECO:0000305};
DE            EC=3.1.26.5 {ECO:0000250|UniProtKB:Q99575};
GN   Name=popl-1 {ECO:0000312|WormBase:C05D11.9};
GN   ORFNames=C05D11.9 {ECO:0000312|WormBase:C05D11.9};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that
CC       generates mature tRNA molecules by cleaving their 5'-ends (By
CC       similarity). Also a component of the MRP ribonuclease complex, which
CC       cleaves pre-rRNA sequences (By similarity).
CC       {ECO:0000250|UniProtKB:Q99575}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC         from tRNA precursor.; EC=3.1.26.5;
CC         Evidence={ECO:0000250|UniProtKB:Q99575};
CC   -!- SUBUNIT: Component of nuclear RNase P and RNase MRP ribonucleoproteins
CC       (By similarity). Several subunits of RNase P are also part of the RNase
CC       MRP complex (By similarity). {ECO:0000250|UniProtKB:Q99575}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q99575}.
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DR   EMBL; BX284603; CCD63199.1; -; Genomic_DNA.
DR   PIR; E88482; E88482.
DR   RefSeq; NP_498408.1; NM_066007.5.
DR   AlphaFoldDB; Q11188; -.
DR   SMR; Q11188; -.
DR   STRING; 6239.C05D11.9; -.
DR   EPD; Q11188; -.
DR   PaxDb; Q11188; -.
DR   PeptideAtlas; Q11188; -.
DR   EnsemblMetazoa; C05D11.9.1; C05D11.9.1; WBGene00015486.
DR   GeneID; 175911; -.
DR   KEGG; cel:CELE_C05D11.9; -.
DR   UCSC; C05D11.9; c. elegans.
DR   CTD; 175911; -.
DR   WormBase; C05D11.9; CE24787; WBGene00015486; popl-1.
DR   eggNOG; KOG3322; Eukaryota.
DR   GeneTree; ENSGT00390000017478; -.
DR   HOGENOM; CLU_007205_1_1_1; -.
DR   InParanoid; Q11188; -.
DR   OMA; NCVIRDR; -.
DR   OrthoDB; 543991at2759; -.
DR   PhylomeDB; Q11188; -.
DR   PRO; PR:Q11188; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00015486; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005655; C:nucleolar ribonuclease P complex; IBA:GO_Central.
DR   GO; GO:0000172; C:ribonuclease MRP complex; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0090502; P:RNA phosphodiester bond hydrolysis, endonucleolytic; IBA:GO_Central.
DR   GO; GO:0001682; P:tRNA 5'-leader removal; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IBA:GO_Central.
DR   InterPro; IPR039182; Pop1.
DR   InterPro; IPR009723; Pop1_N.
DR   InterPro; IPR012590; POPLD_dom.
DR   PANTHER; PTHR22731; PTHR22731; 1.
DR   Pfam; PF06978; POP1; 2.
DR   Pfam; PF08170; POPLD; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Nucleus; Reference proteome; RNA-binding; tRNA processing.
FT   CHAIN           1..752
FT                   /note="Ribonucleases P/MRP protein subunit popl-1"
FT                   /id="PRO_0000065150"
FT   REGION          638..663
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        641..657
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   752 AA;  87123 MW;  E8D225644CEE4D1B CRC64;
     MFIEVEKFVE ARTNSIAQLL KAIDNDALVS GEVTKGPRTA AQRLPRHMRR RAMAYDIRRF
     PRTMREFAAA HLISKHAKKC PSRFARRKSA NSRTKFGRST STKGIWLSTH VWHAKRFRMI
     QKWGFKLADR SFQRGFRAVL RDSNKNCVIR DRSYYTCVTI QCTDAYSKIS QFSQKGCRGQ
     SSRDEEEECH QLYMPGKYPF GYIGPARFQR LSGDKVHIWI HPSSKLQFMK ALLEYYNLEK
     QENTEEDLYK NSEIKVSIDA ENICRFHLSG PKCLSKLRDS IRFVNDEKFS SEHNYFLSVS
     DSVFQSSRDG EVINLLIEDP RTTWDRKTVL KHKKVNKEAD NERIRVSKFW NKEFREMAIE
     KRMADSEFHK QNSSKINGVI STEAKVPIIL IIRNEGLKAL DGADILIPEP FAKDFWVSLQ
     RRGVRASGLR DEYAAHLESK ALYYPLDDVG SEAGRESELA MKKELIEKYL GKPHNRRCKH
     WSAVSVKYPF EFKWDELSQD WNLSNKPRSE AFVCRDLQKL RIIEEAMKKG SGLEEFQEPG
     MLIPVKLQFF GRGRPKKYGM VCLPTDDDLI SIRKNRNREI IQTPPEASSQ DSDIVEAMEI
     EEITVKKNQG FMSLEAAASE KPINLKLLFE ETTKLDDKTT KRKRVNRKKR ESKKRRKIEQ
     EKRKEEAEVE EVQKLATKYR FSANREIIGR LVAGEQSVLA GHGVGIGYIC ANTLSLIASN
     YHKSKTVVMV RNSTSKYYHP AYVTILKNAT KI