ID   PORA_CORAY              Reviewed;         386 AA.
AC   C0HJE6;
DT   01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2014, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Porin PorA {ECO:0000303|PubMed:23811360};
DE   Flags: Precursor;
GN   Name=porA {ECO:0000303|PubMed:23811360};
OS   Corynebacterium amycolatum.
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=43765;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 189-199; 276-281; 306-315
RP   AND 333-342, FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 49368 / DSM 6922 / JCM 7447 / KCTC 3432 / NBRC 15207 / NCIMB
RC   13130 / S160 {ECO:0000269|PubMed:23811360};
RX   PubMed=23811360; DOI=10.1016/j.bbamem.2013.06.024;
RA   Soltan Mohammadi N., Mafakheri S., Abdali N., Barcena-Uribarri I.,
RA   Tauch A., Benz R.;
RT   "Identification and characterization of the channel-forming protein in the
RT   cell wall of Corynebacterium amycolatum.";
RL   Biochim. Biophys. Acta 1828:2574-2582(2013).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 49368 / DSM 6922 / JCM 7447 / KCTC 3432 / NBRC 15207 / NCIMB
RC   13130 / S160 {ECO:0000269|PubMed:19440981};
RX   PubMed=19440981;
RA   Dorner U., Schiffler B., Laneelle M.A., Daffe M., Benz R.;
RT   "Identification of a cell-wall channel in the corynemycolic acid-free Gram-
RT   positive bacterium Corynebacterium amycolatum.";
RL   Int. Microbiol. 12:29-38(2009).
CC   -!- FUNCTION: Forms water-filled channels that favor the permeation of
CC       cations. {ECO:0000269|PubMed:19440981, ECO:0000269|PubMed:23811360}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000269|PubMed:19440981,
CC       ECO:0000269|PubMed:23811360, ECO:0000305}. Note=Due to the absence of
CC       corynemycolates in the cell envelope the nature of the permeability
CC       barrier this porin is part of remains unclear.
CC       {ECO:0000269|PubMed:19440981, ECO:0000269|PubMed:23811360,
CC       ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PorA family. {ECO:0000305}.
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DR   AlphaFoldDB; C0HJE6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR021424; PorA.
DR   Pfam; PF11271; PorA; 1.
PE   1: Evidence at protein level;
KW   Cell wall; Direct protein sequencing; Ion transport; Secreted; Signal;
KW   Transport.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..386
FT                   /note="Porin PorA"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000430486"
FT   REGION          53..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..78
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   386 AA;  43366 MW;  C21033EF9174CBCF CRC64;
     MKRTLGHALI IIGAALIVIA VLLPTFLVPR LRVIPLDTVS DTITEVRDGT LLDSSQLGKN
     EPTPNRKNDP RCKAETDEEK RDLPVHCFIN DKTPMQSKRH VEIEEPADEK IATLQVGTTL
     LRDDRKEPKN LINAILDRIT VDRSTAYPVD DPISSVAINA PQGGSDTKPP TFTRPGIQYQ
     FPFGAQKKSY PYYDVQAMRN FEIDFVGEET QDGVKVYKYS MTIPPQNLYE SLTEHFTRDG
     RKLTEADKSS LASMRLSFPA HKWGLEGDDD VELDRYYTNV RTVRVEPTSG VIVNGTEEMF
     MFYAKDDKEA EEIASKAGRE KEAKEQNRTA MKYTAQWDEG SKGRQMDRAK EARKSLTIGG
     TVAPWILGIL GLVPIVIGFR IRSKSA