ID   PORA_METTH              Reviewed;         383 AA.
AC   P56810;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Pyruvate synthase subunit PorA;
DE            EC=1.2.7.1;
DE   AltName: Full=Pyruvate oxidoreductase alpha chain;
DE            Short=POR;
DE   AltName: Full=Pyruvic-ferredoxin oxidoreductase subunit alpha;
GN   Name=porA; OrderedLocusNames=MTH_1739;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA
CC         + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:12765,
CC         Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15361,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33737,
CC         ChEBI:CHEBI:33738, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=1.2.7.1;
CC   -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma
CC       chain.
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DR   EMBL; AE000666; AAB86209.1; -; Genomic_DNA.
DR   PIR; E69099; E69099.
DR   RefSeq; WP_010877345.1; NC_000916.1.
DR   AlphaFoldDB; P56810; -.
DR   SMR; P56810; -.
DR   STRING; 187420.MTH_1739; -.
DR   EnsemblBacteria; AAB86209; AAB86209; MTH_1739.
DR   GeneID; 1470824; -.
DR   KEGG; mth:MTH_1739; -.
DR   PATRIC; fig|187420.15.peg.1698; -.
DR   HOGENOM; CLU_002569_5_0_2; -.
DR   OMA; WNDQQDS; -.
DR   BioCyc; MetaCyc:MON-14529; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0019164; F:pyruvate synthase activity; IEA:UniProtKB-EC.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   InterPro; IPR033412; PFOR_II.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   Pfam; PF17147; PFOR_II; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
DR   SUPFAM; SSF52922; SSF52922; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..383
FT                   /note="Pyruvate synthase subunit PorA"
FT                   /id="PRO_0000099897"
SQ   SEQUENCE   383 AA;  42448 MW;  586DFD585247BF1E CRC64;
     MVLKVISANQ AVAEAAKLAK PKVIPVYPIT PQTSISEYLA KFVADGELKA EYIRVESEHS
     AMSACVGASG AGVRVFTATS SQGLALMHEI VYAAAGLRNP IVMANANRAL SAPLSIWNDQ
     QDSIAERDSG WMQIYVESGQ EALDSVLLSY RVSEDRDVLL PSMVCLDGFI LTHTVEPVDI
     PSQEDVDSFL PEFQPQVMLD PDEPMSLGTF TDPDYYMEAR YEVEKAMERS RKIIERACRE
     FSEMFGREYG LVEEYRCEDA EIILVAMGSV CSTLREVIDE LRDKGKAVGL LKVRVHRPFP
     AEEIKSAVRN ASKVAVLDKN ITFSVGGALY TEISALLRDR EVYGFIVGLG GRDITPAHIE
     EIVRRTENPE RSVTWIGLKE ESE