PORA_PYRAB
ID PORA_PYRAB Reviewed; 395 AA.
AC Q9UYZ4; G8ZHG9;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Pyruvate synthase subunit PorA;
DE EC=1.2.7.1;
DE AltName: Full=Pyruvate oxidoreductase alpha chain;
DE Short=POR;
DE AltName: Full=Pyruvic-ferredoxin oxidoreductase subunit alpha;
GN Name=porA; OrderedLocusNames=PYRAB13630; ORFNames=PAB1475;
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay;
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=GE5 / Orsay;
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA
CC + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:12765,
CC Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15361,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33737,
CC ChEBI:CHEBI:33738, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=1.2.7.1;
CC -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma
CC chain.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ248287; CAB50268.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE70806.1; -; Genomic_DNA.
DR PIR; G75046; G75046.
DR RefSeq; WP_010868478.1; NC_000868.1.
DR AlphaFoldDB; Q9UYZ4; -.
DR SMR; Q9UYZ4; -.
DR STRING; 272844.PAB1475; -.
DR EnsemblBacteria; CAB50268; CAB50268; PAB1475.
DR GeneID; 1496752; -.
DR KEGG; pab:PAB1475; -.
DR PATRIC; fig|272844.11.peg.1449; -.
DR eggNOG; arCOG01608; Archaea.
DR HOGENOM; CLU_002569_5_0_2; -.
DR OMA; WNDQQDS; -.
DR OrthoDB; 29908at2157; -.
DR PhylomeDB; Q9UYZ4; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0019164; F:pyruvate synthase activity; IEA:UniProtKB-EC.
DR CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR InterPro; IPR033412; PFOR_II.
DR InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR Pfam; PF17147; PFOR_II; 1.
DR Pfam; PF01855; POR_N; 1.
DR SUPFAM; SSF52518; SSF52518; 1.
DR SUPFAM; SSF52922; SSF52922; 1.
PE 4: Predicted;
KW Oxidoreductase.
FT CHAIN 1..395
FT /note="Pyruvate synthase subunit PorA"
FT /id="PRO_0000099899"
SQ SEQUENCE 395 AA; 44045 MW; E8E09713008A8083 CRC64;
MPIRTVMKAN EAAAWAAKLA KPKVIAAFPI TPSTLVPEKI SEFVANGELD AEFIKVESEH
SAISALVGAS AAGVRTFTAT ASQGLALMHE VLFIAAGMRL PIVMAIGNRA LSAPINIWND
WQDTISQRDT GWIQFYAENN QEALDLILLA YKVAEDERVL LPAMVGFDAF ILTHTVEPVE
IPDQEVVDEF LGEYEPKHAY LDPKRPITQG TLAFPAHYME ARYLVWEAME NARKVIDEAF
AEFEKKFGRK YQKIEEYRTD DAEIIFVTMG SLAGTLKDWV DKKREEGYKV GAAKMTVYRP
FPVEEIRELA KKTKVLAFIE KDISMGLYGA VFTDASAALI NESEKPLMLD FIAGLGGRDV
TFNQLDEALS IAKEALEKGK VEKPIHWIGL RKELL