ID   PORB_PSEAE              Reviewed;         454 AA.
AC   Q51485; Q9R4Z9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Porin B;
DE   AltName: Full=Glucose porin;
DE   AltName: Full=Outer membrane protein D1;
DE   Flags: Precursor;
GN   Name=oprB; OrderedLocusNames=PA3186;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / PAO1 / H103;
RX   PubMed=8125108; DOI=10.1111/j.1432-1033.1994.tb18649.x;
RA   Wylie J.L., Worobec E.A.;
RT   "Cloning and nucleotide sequence of the Pseudomonas aeruginosa glucose-
RT   selective OprB porin gene and distribution of OprB within the family
RT   Pseudomonadaceae.";
RL   Eur. J. Biochem. 220:505-512(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [3]
RP   CHARACTERIZATION.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=2450582; DOI=10.1016/0005-2736(88)90148-4;
RA   Trias J., Rosenberg E.Y., Nikaido H.;
RT   "Specificity of the glucose channel formed by protein D1 of Pseudomonas
RT   aeruginosa.";
RL   Biochim. Biophys. Acta 938:493-496(1988).
RN   [4]
RP   CHARACTERIZATION, AND PROTEIN SEQUENCE OF 32-48.
RC   STRAIN=H673;
RX   PubMed=8132494; DOI=10.1007/bf01108411;
RA   Wylie J.L., Bernegger-Egli C., O'Neil J.D., Worobec E.A.;
RT   "Biophysical characterization of OprB, a glucose-inducible porin of
RT   Pseudomonas aeruginosa.";
RL   J. Bioenerg. Biomembr. 25:547-556(1993).
RN   [5]
RP   CHARACTERIZATION.
RC   STRAIN=ATCC 15692 / PAO1 / H103;
RX   PubMed=7768797; DOI=10.1128/jb.177.11.3021-3026.1995;
RA   Wylie J.L., Worobec E.A.;
RT   "The OprB porin plays a central role in carbohydrate uptake in Pseudomonas
RT   aeruginosa.";
RL   J. Bacteriol. 177:3021-3026(1995).
CC   -!- FUNCTION: Substrate-selective channel for a variety of different
CC       sugars. Could potentially facilitate the diffusion of diverse
CC       compounds, dependent on the presence of a hydroxyl group, but is
CC       presumably restricted to carbohydrates. Involved in the transport of
CC       glucose, mannitol, fructose and glycerol (sugars able to support the
CC       growth of P.aeruginosa). Facilitates glucose diffusion across the outer
CC       membrane.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: By glucose.
CC   -!- SIMILARITY: Belongs to the OprB family. {ECO:0000305}.
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DR   EMBL; X77131; CAA54387.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG06574.1; -; Genomic_DNA.
DR   PIR; S42207; S42207.
DR   RefSeq; NP_251876.1; NC_002516.2.
DR   RefSeq; WP_003116413.1; NZ_CP053028.1.
DR   AlphaFoldDB; Q51485; -.
DR   SMR; Q51485; -.
DR   STRING; 287.DR97_4750; -.
DR   TCDB; 1.B.19.1.1; the glucose-selective oprb porin (oprb) family.
DR   PaxDb; Q51485; -.
DR   PRIDE; Q51485; -.
DR   EnsemblBacteria; AAG06574; AAG06574; PA3186.
DR   GeneID; 882788; -.
DR   KEGG; pae:PA3186; -.
DR   PATRIC; fig|208964.12.peg.3331; -.
DR   PseudoCAP; PA3186; -.
DR   HOGENOM; CLU_029684_1_0_6; -.
DR   InParanoid; Q51485; -.
DR   OMA; AWSWSTK; -.
DR   PhylomeDB; Q51485; -.
DR   BioCyc; PAER208964:G1FZ6-3246-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IDA:PseudoCAP.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.160.180; -; 1.
DR   InterPro; IPR007049; Carb-sel_porin_OprB.
DR   InterPro; IPR038673; OprB_sf.
DR   Pfam; PF04966; OprB; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Direct protein sequencing; Ion transport; Membrane;
KW   Porin; Reference proteome; Signal; Sugar transport; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000269|PubMed:8132494"
FT   CHAIN           32..454
FT                   /note="Porin B"
FT                   /id="PRO_0000025209"
SQ   SEQUENCE   454 AA;  50754 MW;  2CC180213EA03D08 CRC64;
     MYKNKKTRPA ARTVGCLFAL GALGLGSAAH AAEAFSPNSK WMLGDWGGKR TELLEKGYDF
     KLEYVGEAAA NLDGGYDDDK TGRYTDQFAL GVHMDLEKIL GWKATEFQFT VTERNGKNLS
     NDRIGDPRAG HISSVQEVWG RGQTWRLTQL WLKQQYFDGA LDVKFGRFGE GEDFNSFPCD
     FQNLAFCGSQ VGNWAGSIWY NWPVSQWALR VKYNFAPDWY VQVGAYEQNP SNLETGNGFK
     MSGSGTKGAL LPVELIWQPK VGAEQLPGEY RLGYYYSTAK ADDVYDDVDG QPQGLTGNDF
     KSRGSKHGWW VVAQQQVTSH NGDASRGLSL FANLTVHDKA TNVVDNYQQL GVVYKGPFDA
     RPKDDIGLGI ARIHVNDDVK KRQRLVNQVN GIDDYDNPLY QPLQDTEYNA ELYYGVHVTD
     WLTVRPNLQY IKQPGGVDEV DNALVAGIKI QTVF