ID   PORC_PYRAB              Reviewed;         185 AA.
AC   Q9UYY9; G8ZHH4;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Pyruvate/ketoisovalerate oxidoreductases common subunit gamma;
DE   Includes:
DE     RecName: Full=Pyruvate synthase subunit PorC;
DE              EC=1.2.7.1;
DE     AltName: Full=Pyruvate oxidoreductase gamma chain;
DE              Short=POR;
DE     AltName: Full=Pyruvic-ferredoxin oxidoreductase subunit gamma;
DE   Includes:
DE     RecName: Full=Ketoisovalerate oxidoreductase subunit VorC;
DE              Short=VOR;
DE              EC=1.2.7.7;
DE     AltName: Full=2-oxoisovalerate ferredoxin reductase subunit gamma;
DE     AltName: Full=2-oxoisovalerate oxidoreductase gamma chain;
GN   Name=porG; OrderedLocusNames=PYRAB13680; ORFNames=PAB1470;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA
CC         + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:12765,
CC         Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15361,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33737,
CC         ChEBI:CHEBI:33738, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=1.2.7.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-
CC         [ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-
CC         2S]-[ferredoxin]; Xref=Rhea:RHEA:11712, Rhea:RHEA-COMP:10000,
CC         Rhea:RHEA-COMP:10001, ChEBI:CHEBI:11851, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57338; EC=1.2.7.7;
CC   -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma
CC       chain.
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DR   EMBL; AJ248287; CAB50273.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE70811.1; -; Genomic_DNA.
DR   PIR; D75047; D75047.
DR   RefSeq; WP_010868483.1; NC_000868.1.
DR   AlphaFoldDB; Q9UYY9; -.
DR   SMR; Q9UYY9; -.
DR   STRING; 272844.PAB1470; -.
DR   EnsemblBacteria; CAB50273; CAB50273; PAB1470.
DR   GeneID; 1496757; -.
DR   KEGG; pab:PAB1470; -.
DR   PATRIC; fig|272844.11.peg.1454; -.
DR   eggNOG; arCOG01603; Archaea.
DR   HOGENOM; CLU_087284_2_0_2; -.
DR   OMA; YEIASEW; -.
DR   OrthoDB; 95610at2157; -.
DR   PhylomeDB; Q9UYY9; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity; IEA:UniProtKB-EC.
DR   GO; GO:0019164; F:pyruvate synthase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.920.10; -; 1.
DR   InterPro; IPR011894; PorC_KorC.
DR   InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR   InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR   Pfam; PF01558; POR; 1.
DR   SUPFAM; SSF53323; SSF53323; 1.
DR   TIGRFAMs; TIGR02175; PorC_KorC; 1.
PE   4: Predicted;
KW   Oxidoreductase.
FT   CHAIN           1..185
FT                   /note="Pyruvate/ketoisovalerate oxidoreductases common
FT                   subunit gamma"
FT                   /id="PRO_0000099913"
SQ   SEQUENCE   185 AA;  20023 MW;  2387E6FE6C6A27EC CRC64;
     MIEIRFHGRG GQGAVTAANI LAEAAFIEGK YVQAFPFFGV ERRGAPVTAF TRIDEKPIRI
     KTQIYEPDVV VVLDPSLLET VDVTAGLKED GIVIVNTEKS KEEVLEKLKR KPKKLALVDA
     TTIALETLGL PITNTAILGA VAKATGLVKI ESVETAIKDT FSGELGEKNA KAAREAFEKT
     QIFEV