PORC_PYRHO
ID PORC_PYRHO Reviewed; 185 AA.
AC O58411;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Pyruvate/ketoisovalerate oxidoreductases common subunit gamma;
DE Includes:
DE RecName: Full=Pyruvate synthase subunit PorC;
DE EC=1.2.7.1;
DE AltName: Full=Pyruvate oxidoreductase gamma chain;
DE Short=POR;
DE AltName: Full=Pyruvic-ferredoxin oxidoreductase subunit gamma;
DE Includes:
DE RecName: Full=Ketoisovalerate oxidoreductase subunit VorC;
DE Short=VOR;
DE EC=1.2.7.7;
DE AltName: Full=2-oxoisovalerate ferredoxin reductase subunit gamma;
DE AltName: Full=2-oxoisovalerate oxidoreductase gamma chain;
GN Name=porG; OrderedLocusNames=PH0678;
OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS 100139 / OT-3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=70601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT "Complete sequence and gene organization of the genome of a hyper-
RT thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL DNA Res. 5:55-76(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA
CC + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:12765,
CC Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15361,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33737,
CC ChEBI:CHEBI:33738, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=1.2.7.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-
CC [ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-
CC 2S]-[ferredoxin]; Xref=Rhea:RHEA:11712, Rhea:RHEA-COMP:10000,
CC Rhea:RHEA-COMP:10001, ChEBI:CHEBI:11851, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57338; EC=1.2.7.7;
CC -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma
CC chain.
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DR EMBL; BA000001; BAA29769.1; -; Genomic_DNA.
DR PIR; G71113; G71113.
DR RefSeq; WP_010884771.1; NC_000961.1.
DR AlphaFoldDB; O58411; -.
DR SMR; O58411; -.
DR STRING; 70601.3257086; -.
DR EnsemblBacteria; BAA29769; BAA29769; BAA29769.
DR GeneID; 1443006; -.
DR KEGG; pho:PH0678; -.
DR eggNOG; arCOG01603; Archaea.
DR OMA; YEIASEW; -.
DR OrthoDB; 95610at2157; -.
DR Proteomes; UP000000752; Chromosome.
DR GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity; IEA:UniProtKB-EC.
DR GO; GO:0019164; F:pyruvate synthase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.920.10; -; 1.
DR InterPro; IPR011894; PorC_KorC.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR Pfam; PF01558; POR; 1.
DR SUPFAM; SSF53323; SSF53323; 1.
DR TIGRFAMs; TIGR02175; PorC_KorC; 1.
PE 4: Predicted;
KW Oxidoreductase.
FT CHAIN 1..185
FT /note="Pyruvate/ketoisovalerate oxidoreductases common
FT subunit gamma"
FT /id="PRO_0000099915"
SQ SEQUENCE 185 AA; 20051 MW; 99F746D9E801D0A6 CRC64;
MIEIRFHGRG GQGAVTAANI LAEAAFLEGK YVQAFPFFGV ERRGAPVTAF TRIDEKPIRI
KTQIYEPDIV VVLDPSLLET VDVTAGLKEE GIVIINTEKS KDEILEKLKK KPKKLALVDA
TTIALETLGL PITNTAILGA VAKATGLVNI ESVEKAIKDT FSGELGEKNA KAAREAFEKT
EIFEV
