PORC_THEKO
ID PORC_THEKO Reviewed; 185 AA.
AC Q5JIK2;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Pyruvate/ketoisovalerate oxidoreductases common subunit gamma;
DE Includes:
DE RecName: Full=Pyruvate synthase subunit PorC;
DE EC=1.2.7.1;
DE AltName: Full=Pyruvate oxidoreductase gamma chain;
DE Short=POR;
DE AltName: Full=Pyruvic-ferredoxin oxidoreductase subunit gamma;
DE Includes:
DE RecName: Full=Ketoisovalerate oxidoreductase subunit VorC;
DE Short=VOR;
DE EC=1.2.7.7;
DE AltName: Full=2-oxoisovalerate ferredoxin reductase subunit gamma;
DE AltName: Full=2-oxoisovalerate oxidoreductase gamma chain;
GN Name=porG; OrderedLocusNames=TK1978;
OS Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS (Pyrococcus kodakaraensis (strain KOD1)).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=69014;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX PubMed=15710748; DOI=10.1101/gr.3003105;
RA Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL Genome Res. 15:352-363(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA
CC + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:12765,
CC Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15361,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33737,
CC ChEBI:CHEBI:33738, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=1.2.7.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-
CC [ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-
CC 2S]-[ferredoxin]; Xref=Rhea:RHEA:11712, Rhea:RHEA-COMP:10000,
CC Rhea:RHEA-COMP:10001, ChEBI:CHEBI:11851, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57338; EC=1.2.7.7;
CC -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma
CC chain.
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DR EMBL; AP006878; BAD86167.1; -; Genomic_DNA.
DR RefSeq; WP_011250928.1; NC_006624.1.
DR AlphaFoldDB; Q5JIK2; -.
DR SMR; Q5JIK2; -.
DR STRING; 69014.TK1978; -.
DR EnsemblBacteria; BAD86167; BAD86167; TK1978.
DR GeneID; 3235685; -.
DR KEGG; tko:TK1978; -.
DR PATRIC; fig|69014.16.peg.1932; -.
DR eggNOG; arCOG01603; Archaea.
DR HOGENOM; CLU_087284_2_0_2; -.
DR InParanoid; Q5JIK2; -.
DR OMA; PDYVIVQ; -.
DR OrthoDB; 95610at2157; -.
DR PhylomeDB; Q5JIK2; -.
DR Proteomes; UP000000536; Chromosome.
DR GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity; IEA:UniProtKB-EC.
DR GO; GO:0019164; F:pyruvate synthase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.920.10; -; 1.
DR InterPro; IPR011894; PorC_KorC.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR Pfam; PF01558; POR; 1.
DR SUPFAM; SSF53323; SSF53323; 1.
DR TIGRFAMs; TIGR02175; PorC_KorC; 1.
PE 4: Predicted;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..185
FT /note="Pyruvate/ketoisovalerate oxidoreductases common
FT subunit gamma"
FT /id="PRO_0000099916"
SQ SEQUENCE 185 AA; 19693 MW; 4ACBC76A5E2DD707 CRC64;
MIEIRFHGRG GQGAVTAANI LASAAFKEGK YVQAFPFFGV ERRGAPVTAF TRIDDKPIRI
KTQIYEPDVV VVLDPSLLDT VDVTAGLKDG GIVIVNTEKS KEEVLEKLKK KPGKLALVDA
TGIALEILGL PITNTAILGA VAKATGLVKL ESVQEAIKET FSGALGEKNA KAAEEAFNKT
VVYEL
