ID   PORC_THELN              Reviewed;         185 AA.
AC   P84820; H3ZL65; Q9UWG1;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   14-MAY-2014, sequence version 2.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Pyruvate/ketoisovalerate oxidoreductases common subunit gamma;
DE   Includes:
DE     RecName: Full=Pyruvate synthase subunit PorC;
DE              EC=1.2.7.1;
DE     AltName: Full=Pyruvate oxidoreductase gamma chain;
DE              Short=POR;
DE     AltName: Full=Pyruvic-ferredoxin oxidoreductase subunit gamma;
DE   Includes:
DE     RecName: Full=Ketoisovalerate oxidoreductase subunit VorC;
DE              Short=VOR;
DE              EC=1.2.7.7;
DE     AltName: Full=2-oxoisovalerate ferredoxin reductase subunit gamma;
DE     AltName: Full=2-oxoisovalerate oxidoreductase gamma chain;
GN   Name=porG; ORFNames=OCC_07501;
OS   Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=523849;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51850 / DSM 5473 / JCM 8560 / NS-C;
RX   PubMed=22493191; DOI=10.1128/jb.00123-12;
RA   Gardner A.F., Kumar S., Perler F.B.;
RT   "Genome sequence of the model hyperthermophilic archaeon Thermococcus
RT   litoralis NS-C.";
RL   J. Bacteriol. 194:2375-2376(2012).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 1-15.
RC   STRAIN=ATCC 51850 / DSM 5473 / JCM 8560 / NS-C;
RX   PubMed=8550513; DOI=10.1128/jb.178.3.780-787.1996;
RA   Heider J., Mai X., Adams M.W.W.;
RT   "Characterization of 2-ketoisovalerate ferredoxin oxidoreductase, a new and
RT   reversible coenzyme A-dependent enzyme involved in peptide fermentation by
RT   hyperthermophilic archaea.";
RL   J. Bacteriol. 178:780-787(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA
CC         + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:12765,
CC         Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15361,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33737,
CC         ChEBI:CHEBI:33738, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=1.2.7.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-
CC         [ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-
CC         2S]-[ferredoxin]; Xref=Rhea:RHEA:11712, Rhea:RHEA-COMP:10000,
CC         Rhea:RHEA-COMP:10001, ChEBI:CHEBI:11851, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57338; EC=1.2.7.7;
CC   -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma
CC       chain. {ECO:0000250|UniProtKB:Q51799}.
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DR   EMBL; CP006670; EHR79315.1; -; Genomic_DNA.
DR   RefSeq; WP_004067087.1; NC_022084.1.
DR   AlphaFoldDB; P84820; -.
DR   SMR; P84820; -.
DR   STRING; 523849.OCC_07501; -.
DR   EnsemblBacteria; EHR79315; EHR79315; OCC_07501.
DR   GeneID; 16550288; -.
DR   KEGG; tlt:OCC_07501; -.
DR   HOGENOM; CLU_087284_2_0_2; -.
DR   OMA; YEIASEW; -.
DR   OrthoDB; 95610at2157; -.
DR   BioCyc; MetaCyc:MON-17655; -.
DR   Proteomes; UP000015502; Chromosome.
DR   GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity; IEA:UniProtKB-EC.
DR   GO; GO:0019164; F:pyruvate synthase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.920.10; -; 1.
DR   InterPro; IPR011894; PorC_KorC.
DR   InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR   InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR   Pfam; PF01558; POR; 1.
DR   SUPFAM; SSF53323; SSF53323; 1.
DR   TIGRFAMs; TIGR02175; PorC_KorC; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Oxidoreductase.
FT   CHAIN           1..185
FT                   /note="Pyruvate/ketoisovalerate oxidoreductases common
FT                   subunit gamma"
FT                   /id="PRO_0000233958"
SQ   SEQUENCE   185 AA;  19926 MW;  2A739C51CF0094BC CRC64;
     MIEIRFHGRG GQGAVTAANI LAEAAFLEGK YVQAFPFFGV ERRGAPVTAF TRIDDKPIRI
     KTQIYEPDVV VVLDPSLLDT VDVTAGLKEG GMVIVNTEKT KEEVLEKLKK KPAKLALVDA
     TTIALEILGL PITNTSILGA VAKATGIVKI ESVEEAIKDT FSGELGKKNA KAAREAFEKT
     VVYEL