PORIM_MOUSE
ID PORIM_MOUSE Reviewed; 195 AA.
AC Q91Z22; Q3T9F6; Q3TLL2; Q3U1R6; Q8CEX4;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Porimin;
DE AltName: Full=Transmembrane protein 123;
DE Flags: Precursor;
GN Name=Tmem123;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Bone marrow, Cerebellum, Mammary gland, Spleen, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3, and NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Implicated in oncotic cell death, characterized by cell
CC swelling, organelle swelling, vacuolization and increased membrane
CC permeability. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CD164 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK010163; BAC25282.1; -; mRNA.
DR EMBL; AK150361; BAE29496.1; -; mRNA.
DR EMBL; AK151044; BAE30061.1; -; mRNA.
DR EMBL; AK152180; BAE31011.1; -; mRNA.
DR EMBL; AK152423; BAE31207.1; -; mRNA.
DR EMBL; AK153122; BAE31737.1; -; mRNA.
DR EMBL; AK153539; BAE32076.1; -; mRNA.
DR EMBL; AK155767; BAE33427.1; -; mRNA.
DR EMBL; AK162610; BAE36988.1; -; mRNA.
DR EMBL; AK166444; BAE38780.1; -; mRNA.
DR EMBL; AK170823; BAE42054.1; -; mRNA.
DR EMBL; AK172352; BAE42962.1; -; mRNA.
DR EMBL; AK172553; BAE43065.1; -; mRNA.
DR EMBL; AK172701; BAE43135.1; -; mRNA.
DR EMBL; BC010292; AAH10292.1; -; mRNA.
DR EMBL; BC086319; AAH86319.1; -; mRNA.
DR CCDS; CCDS22810.1; -.
DR RefSeq; NP_598500.1; NM_133739.2.
DR AlphaFoldDB; Q91Z22; -.
DR SMR; Q91Z22; -.
DR STRING; 10090.ENSMUSP00000051966; -.
DR GlyGen; Q91Z22; 6 sites.
DR iPTMnet; Q91Z22; -.
DR PhosphoSitePlus; Q91Z22; -.
DR MaxQB; Q91Z22; -.
DR PaxDb; Q91Z22; -.
DR PeptideAtlas; Q91Z22; -.
DR PRIDE; Q91Z22; -.
DR ProteomicsDB; 291772; -.
DR Antibodypedia; 31754; 154 antibodies from 27 providers.
DR DNASU; 71929; -.
DR Ensembl; ENSMUST00000052865; ENSMUSP00000051966; ENSMUSG00000050912.
DR GeneID; 71929; -.
DR KEGG; mmu:71929; -.
DR UCSC; uc009ocx.2; mouse.
DR CTD; 114908; -.
DR MGI; MGI:1919179; Tmem123.
DR VEuPathDB; HostDB:ENSMUSG00000050912; -.
DR eggNOG; ENOG502SAV2; Eukaryota.
DR GeneTree; ENSGT00530000063929; -.
DR HOGENOM; CLU_121016_0_0_1; -.
DR InParanoid; Q91Z22; -.
DR OMA; FSANLCD; -.
DR OrthoDB; 1551427at2759; -.
DR PhylomeDB; Q91Z22; -.
DR TreeFam; TF350123; -.
DR BioGRID-ORCS; 71929; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Tmem123; mouse.
DR PRO; PR:Q91Z22; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q91Z22; protein.
DR Bgee; ENSMUSG00000050912; Expressed in peripheral lymph node and 257 other tissues.
DR ExpressionAtlas; Q91Z22; baseline and differential.
DR Genevisible; Q91Z22; MM.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0070267; P:oncosis; ISO:MGI.
DR InterPro; IPR007947; CD164_MGC24.
DR PANTHER; PTHR11337; PTHR11337; 1.
DR Pfam; PF05283; MGC-24; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..195
FT /note="Porimin"
FT /id="PRO_0000045059"
FT TOPO_DOM 24..152
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 99..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 187
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 25
FT /note="D -> E (in Ref. 1; BAE42962/BAE43065/BAE43135)"
FT /evidence="ECO:0000305"
FT CONFLICT 68
FT /note="A -> V (in Ref. 1; BAE38780)"
FT /evidence="ECO:0000305"
FT CONFLICT 106
FT /note="S -> T (in Ref. 1; BAE33427)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="L -> W (in Ref. 1; BAC25282)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 195 AA; 20178 MW; 64024F8550ABC248 CRC64;
MALCARAALL LGVLQVLALL GAAQDPTDAQ GSASGNHSVL TSNINITENT NQTMSVVSNQ
TSEMQSTAKP SVLPKTTTLI TVKPATIVKI STPGVLPHVT PTASKSTPNA SASPNSTHTS
ASMTTPAHSS LLTTVTVSAT THPTKGKGSK FDAGSFVGGI VLTLGVLSIL YIGCKMYYSR
RGIRYRSIDE HDAII
