ID   PORIM_RAT               Reviewed;         194 AA.
AC   Q5HZB0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Porimin;
DE   AltName: Full=Transmembrane protein 123;
DE   Flags: Precursor;
GN   Name=Tmem123;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Implicated in oncotic cell death, characterized by cell
CC       swelling, organelle swelling, vacuolization and increased membrane
CC       permeability. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CD164 family. {ECO:0000305}.
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DR   EMBL; BC089103; AAH89103.1; -; mRNA.
DR   RefSeq; NP_001014227.1; NM_001014205.1.
DR   AlphaFoldDB; Q5HZB0; -.
DR   SMR; Q5HZB0; -.
DR   STRING; 10116.ENSRNOP00000014065; -.
DR   GlyGen; Q5HZB0; 6 sites.
DR   iPTMnet; Q5HZB0; -.
DR   PhosphoSitePlus; Q5HZB0; -.
DR   PaxDb; Q5HZB0; -.
DR   Ensembl; ENSRNOT00000014065; ENSRNOP00000014065; ENSRNOG00000010584.
DR   GeneID; 363013; -.
DR   KEGG; rno:363013; -.
DR   UCSC; RGD:1305625; rat.
DR   CTD; 114908; -.
DR   RGD; 1305625; Tmem123.
DR   eggNOG; ENOG502SAV2; Eukaryota.
DR   GeneTree; ENSGT00530000063929; -.
DR   InParanoid; Q5HZB0; -.
DR   OrthoDB; 1551427at2759; -.
DR   PhylomeDB; Q5HZB0; -.
DR   PRO; PR:Q5HZB0; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR   GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070267; P:oncosis; ISO:RGD.
DR   InterPro; IPR007947; CD164_MGC24.
DR   PANTHER; PTHR11337; PTHR11337; 1.
DR   Pfam; PF05283; MGC-24; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..194
FT                   /note="Porimin"
FT                   /id="PRO_0000045060"
FT   TOPO_DOM        25..151
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        173..194
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          88..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..124
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         186
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91Z22"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        59
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   194 AA;  19984 MW;  C603814422A186F3 CRC64;
     MALCARAALL LGALQVLALP GAVAQETYAQ GSPSGNHSVP LLTANVNVTE NTTMQVVSNQ
     TSQISTVKPS SVLPKNVTAA TVRPATIKVS TPGVSPHVTP SASKSTPKTS ASPNSTQTSA
     SMTTTAHSSL LTSVTVSATT HPTKGKGSKF DAGSFVGGIV LTLGVLSILY IGCKMYYSRR
     GIRYRSIDEH DAII