ID   PORTL_BP234             Reviewed;         448 AA.
AC   A7XXB9;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   02-JUN-2021, entry version 27.
DE   RecName: Full=Portal protein {ECO:0000303|PubMed:30737287};
DE   AltName: Full=Gene product 86 {ECO:0000305};
DE            Short=gp86 {ECO:0000305};
GN   ORFNames=P23p86 {ECO:0000303|PubMed:18355836};
OS   Thermus virus P23-45 (Thermus thermophilus phage P23-45).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Oshimavirus.
OX   NCBI_TaxID=466051;
OH   NCBI_TaxID=274; Thermus thermophilus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18355836; DOI=10.1016/j.jmb.2008.02.018;
RA   Minakhin L., Goel M., Berdygulova Z., Ramanculov E., Florens L., Glazko G.,
RA   Karamychev V.N., Slesarev A.I., Kozyavkin S.A., Khromov I., Ackermann H.W.,
RA   Washburn M., Mushegian A., Severinov K.;
RT   "Genome comparison and proteomic characterization of Thermus thermophilus
RT   bacteriophages P23-45 and P74-26: siphoviruses with triplex-forming
RT   sequences and the longest known tails.";
RL   J. Mol. Biol. 378:468-480(2008).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=30737287; DOI=10.1073/pnas.1813204116;
RA   Bayfield O.W., Klimuk E., Winkler D.C., Hesketh E.L., Chechik M., Cheng N.,
RA   Dykeman E.C., Minakhin L., Ranson N.A., Severinov K., Steven A.C.,
RA   Antson A.A.;
RT   "Cryo-EM structure and in vitro DNA packaging of a thermophilic virus with
RT   supersized T=7 capsids.";
RL   Proc. Natl. Acad. Sci. U.S.A. 116:3556-3561(2019).
CC   -!- FUNCTION: Forms the portal vertex of the capsid (By similarity). This
CC       portal plays critical roles in head assembly, genome packaging,
CC       neck/tail attachment, and genome ejection (By similarity). The portal
CC       protein multimerizes as a single ring-shaped homododecamer arranged
CC       around a central channel (By similarity). Forms the portal vertex of
CC       the capsid. This portal plays critical roles in head assembly, genome
CC       packaging, neck/tail attachment, and genome ejection (By similarity).
CC       {ECO:0000250|UniProtKB:A0A1L4BKQ4}.
CC   -!- SUBUNIT: Homododecamer (By similarity). Interacts with the capsid
CC       protein (By similarity). Interacts with the terminase large subunit;
CC       this interaction allows the packaging of viral DNA (By similarity).
CC       {ECO:0000250|UniProtKB:A0A1L4BKQ4, ECO:0000250|UniProtKB:P26744}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:A0A1L4BKQ4}.
CC       Note=Located at a unique vertex of the capsid.
CC       {ECO:0000250|UniProtKB:A0A1L4BKQ4}.
CC   -!- SIMILARITY: Belongs to the P23virus portal protein family.
CC       {ECO:0000305}.
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DR   EMBL; EU100883; ABU96919.1; -; Genomic_DNA.
DR   RefSeq; YP_001467939.1; NC_009803.1.
DR   PDB; 6QJT; EM; 3.74 A; A=1-448.
DR   PDBsum; 6QJT; -.
DR   SMR; A7XXB9; -.
DR   GeneID; 5600471; -.
DR   KEGG; vg:5600471; -.
DR   Proteomes; UP000001132; Genome.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Reference proteome; Viral capsid assembly;
KW   Viral genome packaging; Viral release from host cell; Virion.
FT   CHAIN           1..448
FT                   /note="Portal protein"
FT                   /id="PRO_0000447192"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   448 AA;  49654 MW;  8BDD69ACA6E3D7DF CRC64;
     MAKRGRKPKE LVPGPGSIDP SDVPKLEGAS VPVMSTSYDV VVDREFDELL QGKDGLLVYH
     KMLSDGTVKN ALNYIFGRIR SAKWYVEPAS TDPEDIAIAA FIHAQLGIDD ASVGKYPFGR
     LFAIYENAYI YGMAAGEIVL TLGADGKLIL DKIVPIHPFN IDEVLYDEEG GPKALKLSGE
     VKGGSQFVNG LEIPIWKTVV FLHNDDGSFT GQSALRAAVP HWLAKRALIL LINHGLERFM
     IGVPTLTIPK SVRQGTKQWE AAKEIVKNFV QKPRHGIILP DDWKFDTVDL KSAMPDAIPY
     LTYHDAGIAR ALGIDFNTVQ LNMGVQAVNI GEFVSLTQQT IISLQREFAS AVNLYLIPKL
     VLPNWPGATR FPRLTFEMEE RNDFSAAANL MGMLINAVKD SEDIPTELKA LIDALPSKMR
     RALGVVDEVR EAVRQPADSR YLYTRRRR