PORTL_BP44A
ID PORTL_BP44A Reviewed; 249 AA.
AC Q859K6;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 29-SEP-2021, entry version 52.
DE RecName: Full=Portal protein {ECO:0000250|UniProtKB:P04332};
DE AltName: Full=Connector protein {ECO:0000250|UniProtKB:P04332};
DE AltName: Full=Gene product 19 {ECO:0000250|UniProtKB:P04332};
DE Short=gp19 {ECO:0000250|UniProtKB:P04332};
DE AltName: Full=Head-to-tail connector {ECO:0000250|UniProtKB:P04332};
DE AltName: Full=Probable portal protein {ECO:0000250|UniProtKB:P04332};
DE AltName: Full=Upper collar protein {ECO:0000250|UniProtKB:P04332};
OS Staphylococcus phage 44AHJD.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Rountreeviridae; Rakietenvirinae; Rosenblumvirus.
OX NCBI_TaxID=204086 {ECO:0000312|Proteomes:UP000007462};
OH NCBI_TaxID=1280; Staphylococcus aureus.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=12620632; DOI=10.1016/s0378-1097(03)00028-4;
RA Vybiral D., Takac M., Loessner M., Witte A., von Ahsen U., Blasi U.;
RT "Complete nucleotide sequence and molecular characterization of two lytic
RT Staphylococcus aureus phages: 44AHJD and P68.";
RL FEMS Microbiol. Lett. 219:275-283(2003).
CC -!- FUNCTION: Forms the portal vertex of the capsid. This portal plays
CC critical roles in head assembly, genome packaging, neck/tail
CC attachment, and genome ejection. The portal protein multimerizes as a
CC single ring-shaped homododecamer arranged around a central channel.
CC Binds to the 6 packaging RNA molecules (pRNA) forming a double-ring
CC structure which in turn binds to the ATPase gp16 hexamer, forming the
CC active DNA-translocating motor. This complex is essential for the
CC specificity of packaging from the left DNA end.
CC {ECO:0000250|UniProtKB:P04332, ECO:0000250|UniProtKB:P13334}.
CC -!- SUBUNIT: Homododecamer. Interacts with the pRNA.
CC {ECO:0000250|UniProtKB:P04332}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P04332}.
CC Note=Present in 12 copies in the virion.
CC {ECO:0000250|UniProtKB:P04332}.
CC -!- SIMILARITY: Belongs to the phi29likevirus portal protein family.
CC {ECO:0000305}.
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DR EMBL; AF513032; AAO83871.1; -; Genomic_DNA.
DR RefSeq; NP_817313.1; NC_004678.1.
DR SMR; Q859K6; -.
DR GeneID; 1258929; -.
DR KEGG; vg:1258929; -.
DR Proteomes; UP000007462; Genome.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0099002; P:viral genome ejection through host cell envelope, short tail mechanism; IEA:UniProtKB-KW.
DR InterPro; IPR008016; Gp10.
DR InterPro; IPR036199; Gp10_sf.
DR Pfam; PF05352; Phage_connector; 1.
DR SUPFAM; SSF56826; SSF56826; 1.
PE 3: Inferred from homology;
KW Capsid protein; Late protein; Reference proteome; RNA-binding;
KW Viral capsid assembly; Viral genome ejection through host cell envelope;
KW Viral genome packaging; Viral penetration into host cytoplasm;
KW Viral release from host cell; Viral short tail ejection system; Virion;
KW Virus entry into host cell.
FT CHAIN 1..249
FT /note="Portal protein"
FT /id="PRO_0000432922"
SQ SEQUENCE 249 AA; 28563 MW; 3D99BDC40CC15E68 CRC64;
MILGYVNNTY FNQAPNFSSN FNFQFQKRLT KEDIYFIVPD YLIPDDCLQI HKLYDNCMSG
NFVVMQNKPI QYNSDIEIIE HYTDELAEVA LSRFSLIMQA KFSKIFKSEI NDESINQLVS
EIYNGAPFVK MSPMFNADDD IIDLTSNSVI PALTEMKREY QNKISELSNY LGINSLAVDK
ESGVSDEEAK SNRGFTTSNS NIYLKGREPI TFLSKRYGLD IKPYYDDETT SKISMVDTLF
KDESSDING
