ID   PORTL_BPHK7             Reviewed;         424 AA.
AC   P49859;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Portal protein;
DE   AltName: Full=GP3;
GN   Name=3;
OS   Enterobacteria phage HK97 (Bacteriophage HK97).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Hendrixvirinae; Byrnievirus.
OX   NCBI_TaxID=2681617;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7723020; DOI=10.1016/s0022-2836(05)80144-5;
RA   Duda R.L., Martincic K., Hendrix R.W.;
RT   "Genetic basis of bacteriophage HK97 prohead assembly.";
RL   J. Mol. Biol. 247:636-647(1995).
CC   -!- FUNCTION: Forms the portal vertex of the capsid. This portal plays
CC       critical roles in head assembly, genome packaging, neck/tail
CC       attachment, and genome ejection. The portal protein multimerizes as a
CC       single ring-shaped homododecamer arranged around a central channel.
CC       Binds to the terminase subunits to form the packaging machine.
CC       {ECO:0000250|UniProtKB:P25480}.
CC   -!- SUBUNIT: Homododecamer. {ECO:0000250|UniProtKB:P25480}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P25480}.
CC   -!- SIMILARITY: Belongs to the phage portal family. HK97 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U18319; AAA80202.1; -; Genomic_DNA.
DR   PIR; S54390; S54390.
DR   RefSeq; NP_037699.1; NC_002167.1.
DR   GeneID; 1262529; -.
DR   KEGG; vg:1262529; -.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0099001; P:viral genome ejection through host cell envelope, long flexible tail mechanism; IEA:UniProtKB-KW.
DR   InterPro; IPR006944; Phage/GTA_portal.
DR   InterPro; IPR006427; Portal_HK97.
DR   Pfam; PF04860; Phage_portal; 1.
DR   TIGRFAMs; TIGR01537; portal_HK97; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Viral capsid assembly;
KW   Viral genome ejection through host cell envelope; Viral genome packaging;
KW   Viral long flexible tail ejection system;
KW   Viral penetration into host cytoplasm; Viral release from host cell;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..424
FT                   /note="Portal protein"
FT                   /id="PRO_0000065885"
SQ   SEQUENCE   424 AA;  47267 MW;  DD75FDCFD11947E1 CRC64;
     MEEPKYTIDL RTNNGWWARL KSWFVGGRLV TPNQGSQTGP VSAHGYLGDS SINDERILQI
     STVWRCVSLI STLTACLPLD VFETDQNDNR KKVDLSNPLA RLLRYSPNQY MTAQEFREAM
     TMQLCFYGNA YALVDRNSAG DVISLLPLQS ANMDVKLVGK KVVYRYQRDS EYADFSQKEI
     FHLKGFGFTG LVGLSPIAFA CKSAGVAVAM EDQQRDFFAN GAKSPQILST GEKVLTEQQR
     SQVEENFKEI AGGPVKKRLW ILEAGFSTSA IGVTPQDAEM MASRKFQVSE LARFFGVPPH
     LVGDVEKSTS WGSGIEQQNL GFLQYTLQPY ISRWENSIQR WLIPSKDVGR LHAEHNLDGL
     LRGDSASRAA FMKAMGESGL RTINEMRRTD NMPPLPGGDV AMRQAQYVPI TDLGTNKEPR
     NNGA