PORTL_BPLP2
ID PORTL_BPLP2 Reviewed; 378 AA.
AC D3WAC3;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 12-AUG-2020, entry version 14.
DE RecName: Full=Probable portal protein {ECO:0000303|PubMed:24027307};
DE AltName: Full=Gene product 4 {ECO:0000305};
DE Short=gp4 {ECO:0000305};
OS Lactococcus phage p2 (Lactococcus lactis bacteriophage p2).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Siphoviridae; Skunavirus.
OX NCBI_TaxID=254252;
OH NCBI_TaxID=1358; Lactococcus lactis.
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tremblay D.M., Deveau H., Moineau S.;
RT "Complete genomic sequence of Lactococcus lactis phage p2.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP STRUCTURE BY ELECTRON MICROSCOPY (13 ANGSTROMS) OF THE CAPSID, FUNCTION,
RP SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=24027307; DOI=10.1128/jvi.02033-13;
RA Bebeacua C., Tremblay D., Farenc C., Chapot-Chartier M.P., Sadovskaya I.,
RA van Heel M., Veesler D., Moineau S., Cambillau C.;
RT "Structure, adsorption to host, and infection mechanism of virulent
RT lactococcal phage p2.";
RL J. Virol. 87:12302-12312(2013).
CC -!- FUNCTION: Forms the portal vertex of the capsid. This portal plays
CC critical roles in head assembly, genome packaging, neck/tail
CC attachment, and genome ejection. The portal protein multimerizes as a
CC single ring-shaped homododecamer arranged around a central channel.
CC Binds to the terminase subunits to form the packaging machine.
CC Necessary to ensure correct procapsid size during capsid assembly. Once
CC the capsid is packaged with the DNA, the terminase complex is
CC substituted by the connector proteins gp15.
CC {ECO:0000305|PubMed:24027307}.
CC -!- SUBUNIT: Homododecamer. {ECO:0000305|PubMed:24027307}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:24027307}.
CC Note=Occupies the twelfth vertex of the capsid.
CC {ECO:0000305|PubMed:24027307}.
CC -!- SIMILARITY: Belongs to the skunalikevirus portal protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GQ979703; ADC80080.1; -; Genomic_DNA.
DR Proteomes; UP000002348; Genome.
DR GO; GO:0046798; C:viral portal complex; IDA:UniProtKB.
DR GO; GO:0099001; P:viral genome ejection through host cell envelope, long flexible tail mechanism; IEA:UniProtKB-KW.
DR InterPro; IPR006944; Phage/GTA_portal.
DR Pfam; PF04860; Phage_portal; 1.
PE 1: Evidence at protein level;
KW Capsid protein; Reference proteome; Viral capsid assembly;
KW Viral genome ejection through host cell envelope; Viral genome packaging;
KW Viral long flexible tail ejection system;
KW Viral penetration into host cytoplasm; Viral release from host cell;
KW Virion; Virus entry into host cell.
FT CHAIN 1..378
FT /note="Probable portal protein"
FT /id="PRO_0000438222"
SQ SEQUENCE 378 AA; 43276 MW; 76FA9700DB766B7D CRC64;
MNLFGKVVSF SRGKLNNDTQ RVTAWQNEAV EYTSAFVTNI HNKIANEITK VEFNHVKYKK
SDVGSDTLIS MAGSDLDEVL NWSPKGERNS MDFWRKVIKK LLRAPYVDLY AVFDDNTGEL
LDLLFADDKK EYKPEELVRL TSPFYINEDT SILDNALASI QTKLEQGKLR GLLKINAFLD
IDNTQEYREK ALTTIKNMQE GSSYNGLTPV DNKTEIVELK KDYSVLNKDE IDLIKSELLT
GYFMNENILL GTASQEQQIY FYNSTIIPLL IQLEKELTYK LISTNRRRVV KGNLYYERII
VDNQLFKFAT LKELIDLYHE NINGPIFTQN QLLVKMGEQP IEGGDVYIAN LNAVAVKNLS
DLQGSRKDVT STDETNNQ