ID   PORTL_BPPHE             Reviewed;         574 AA.
AC   A8E264;
DT   01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   02-JUN-2021, entry version 32.
DE   RecName: Full=Probable portal protein;
GN   ORFNames=EFP_012 {ECO:0000312|EMBL:BAF81280.1};
OS   Enterococcus phage phiEF24C (Enterococcus bacteriophage phi-EF24C).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Herelleviridae; Brockvirinae; Kochikohdavirus;
OC   Enterococcus virus EF24C.
OX   NCBI_TaxID=442493 {ECO:0000312|Proteomes:UP000001151};
OH   NCBI_TaxID=1351; Enterococcus faecalis (Streptococcus faecalis).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PhiEF24C {ECO:0000312|EMBL:BAF81280.1};
RX   PubMed=18456848; DOI=10.1128/aem.02371-07;
RA   Uchiyama J., Rashel M., Takemura I., Wakiguchi H., Matsuzaki S.;
RT   "In silico and in vivo evaluation of bacteriophage phiEF24C, a candidate
RT   for treatment of Enterococcus faecalis infections.";
RL   Appl. Environ. Microbiol. 74:4149-4163(2008).
CC   -!- FUNCTION: Forms the portal vertex of the capsid. This portal plays
CC       critical roles in head assembly, genome packaging, neck/tail
CC       attachment, and genome ejection. The portal protein multimerizes as a
CC       single ring-shaped homododecamer arranged around a central channel.
CC       Binds to the terminase subunits to form the packaging machine.
CC       {ECO:0000250|UniProtKB:P25480}.
CC   -!- SUBUNIT: Homododecamer. {ECO:0000250|UniProtKB:P25480}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P25480}.
CC   -!- SIMILARITY: Belongs to the phage portal family. {ECO:0000305}.
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DR   EMBL; AP009390; BAF81280.1; -; Genomic_DNA.
DR   RefSeq; YP_001504121.1; NC_009904.1.
DR   GeneID; 5666445; -.
DR   KEGG; vg:5666445; -.
DR   Proteomes; UP000001151; Genome.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0099000; P:viral genome ejection through host cell envelope, contractile tail mechanism; IEA:UniProtKB-KW.
DR   InterPro; IPR006944; Phage/GTA_portal.
DR   Pfam; PF04860; Phage_portal; 1.
PE   3: Inferred from homology;
KW   Capsid protein; DNA-binding; Reference proteome; Viral capsid assembly;
KW   Viral contractile tail ejection system;
KW   Viral genome ejection through host cell envelope; Viral genome packaging;
KW   Viral penetration into host cytoplasm; Viral release from host cell;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..574
FT                   /note="Probable portal protein"
FT                   /id="PRO_0000432537"
FT   REGION          504..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..524
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..574
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   574 AA;  64932 MW;  2CFE361F208CE295 CRC64;
     MPKWLDKALG IEKSSIEETR NMENYKMHLR EIDTNVVNNE PYSMESIEKG MNGKTTAYMQ
     PIIGEMSVNP GYKTKPSIRN SQDLHKTLKK FGNNIILNAI INTRSNQVSM YCKPARNSET
     GVGYEIRLKD IEAEPTSHDI ANIKRIESFL ENTAQFRDPN RDNFTTFCKK LVRATYMYDQ
     VNFEKVFDKD GNFIKFDTVD PTTIFLATNG EGKLIKNGER FVQVIDNRIV AKFNERELAF
     AVRNPRADIE VGQYGYPELE IALKQFIAHE NTEVFNDRFF SHGGTTRGIL HVKTGQQQSQ
     QALDIFRREW RSSLAGINGS WQIPVVSAED VKFVNMTPSA NDMQFEKWLN YLINVISALY
     GIDPAEINFP NNGGATGSKG GSLNEGNSKE KMQASQNKGL QPLLRFIEDT VNTYIVAEFG
     EKYQFQFRGG DLSAQLDKLK IIEQEGKVFR TVNEIRHDKG LEPIKGGDVI LNGVHIQAIG
     QALQEEQLEY QRSQDRLNRL LELSGGDVEQ PEPEEPKDSQ NDTDVSFQDE QQGLNGKSKK
     VNGKVDDNVG KDGQLKSEEN TNSTKHGTDG IKKE