ID   PORTL_GAHVM             Reviewed;         722 AA.
AC   Q9E6R0;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Portal protein {ECO:0000255|HAMAP-Rule:MF_04012};
GN   Name=MDV018;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Forms a portal in the viral capsid through which viral DNA is
CC       translocated during DNA packaging. Assembles as a dodecamer at a single
CC       fivefold axe of the T=16 icosahedric capsid. Binds to the molecular
CC       motor that translocates the viral DNA, termed terminase.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBUNIT: Homododecamerizes. Interacts with terminase subunits TRM1 and
CC       TRM3. {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04012}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SIMILARITY: Belongs to the herpesviridae portal protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
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DR   EMBL; AF243438; AAG14198.1; -; Genomic_DNA.
DR   RefSeq; YP_001033934.1; NC_002229.3.
DR   GeneID; 4811479; -.
DR   KEGG; vg:4811479; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044423; C:virion component; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04012; HSV_PORTL; 1.
DR   InterPro; IPR002660; Herpes_Portal.
DR   Pfam; PF01763; Herpes_UL6; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Host nucleus; Reference proteome; Viral genome packaging;
KW   Viral release from host cell; Virion.
FT   CHAIN           1..722
FT                   /note="Portal protein"
FT                   /id="PRO_0000406543"
FT   REGION          402..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..469
FT                   /note="Putative leucine zipper motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04012"
FT   REGION          658..722
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..425
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        658..685
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        686..700
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        701..722
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        183
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04012"
FT   DISULFID        280
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04012"
SQ   SEQUENCE   722 AA;  82411 MW;  E28B695EEC6A5A24 CRC64;
     MDGYDRRAPY DLNSRKINHP DFESVMSQRD TFNNVSSKQC MENQWIVIHP TRQTRMFKEI
     LAGRLGYTDG QGIYNSVRST ETAIRQIQNT ILTLSLDAVR YDDLKNDWIR HADMRGMSAK
     KLARTYGMHS EAEAVKVAEN VFVTWRKTLQ TTLINLARQL ISCFTTANIN TSSFSKYIDW
     ICCLGIVPVV RHDRSARATS SIPTCAGRST VFPNWAFHDA SSRLRVVDSV MARGKQIVNY
     LSNSMSAVSI LEYDRTLIEY NFFKRELRVK DILSGERGEC IVIWRPVMND GGVIFDSPMQ
     RIYKEIIECH DLRQHATLCR LVNTAPVKVL IAKRDDGCKG VAGAQRVIDK VLGDQPENAA
     SSAASRLVKL IIGLKGMRHV GDITDTVRDY LEETSGHLLD AASIDTSQPG FGQSNRAQSS
     TTEETRRNTI KIRDAFHSSV VTSINEMLEG YVNKLFNTVE GLKAANKDLL AKLCSKELEL
     DRVRTEHLIS KQAHTDMGNS QYSPTLETLA RDLKHDVIDV GEVMDDDSYV ANSFQSRYIP
     AYDVDLKRLS ELWEQEMLRC FKLTRATNNQ GHEVSISYSN SAITLLLAPY FFSVLNIYDI
     GPIVTNHEVY KSEEELCNSV FEKTRIHVYL DDLALIFNAD VKRAIAKYFL VRNNSGRQRE
     AEDLPDGHHG RRNDFHSPSS RRERYSRRSG YKRHRWNRES RRDYRRTQST TNGEDDDGSQ
     RD