ID   PORTL_HCMVA             Reviewed;         697 AA.
AC   P16735; Q7M6T5;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Portal protein {ECO:0000255|HAMAP-Rule:MF_04012};
GN   Name=UL104;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT   HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [5]
RP   ERRATUM OF PUBMED:15452216.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
RN   [6]
RP   SEQUENCE REVISION TO 157.
RA   Davison A.J.;
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Forms a portal in the viral capsid through which viral DNA is
CC       translocated during DNA packaging. Assembles as a dodecamer at a single
CC       fivefold axe of the T=16 icosahedric capsid. Binds to the molecular
CC       motor that translocates the viral DNA, termed terminase.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBUNIT: Homododecamerizes. Interacts with terminase subunits TRM1 and
CC       TRM3. {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04012}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SIMILARITY: Belongs to the herpesviridae portal protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
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DR   EMBL; X17403; CAA35341.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00099.2; -; Genomic_DNA.
DR   PIR; S09870; QQBEK3.
DR   PDB; 7ET2; EM; 4.20 A; A/B/C/D/E/F/G/H/I/J/K/L=1-697.
DR   PDB; 7ETM; EM; 5.90 A; A/B/C/D/E/F/G/H/I/J/K/L=1-697.
DR   PDBsum; 7ET2; -.
DR   PDBsum; 7ETM; -.
DR   SMR; P16735; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044423; C:virion component; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04012; HSV_PORTL; 1.
DR   InterPro; IPR002660; Herpes_Portal.
DR   Pfam; PF01763; Herpes_UL6; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Host nucleus; Reference proteome; Viral genome packaging;
KW   Viral release from host cell; Virion.
FT   CHAIN           1..697
FT                   /note="Portal protein"
FT                   /id="PRO_0000115913"
FT   REGION          633..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        661..685
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   697 AA;  78521 MW;  4A86400FDC16AAFA CRC64;
     MERNHWNEKS SGAKRSRERD LTLSTIRSIL AADERLRIKA SSYLGVGRGV DDEAVIDIFP
     TGQTMSFLRL LHGFLGTCRG QSMHQVLRDP CVLRKQLLYG VCKTLFDTIT VRRVAEEWKL
     HAALFPYRAL DEEDLEQYLL VWSASLRQSV QTGVLGALRD ILYQYADNDD YGLYVDWCVT
     VGLVPLLDVK TKPSEAAERA QFVRAAVQRA TETHPLAQDL LQANLALLLQ VAERLGAVRV
     ANAPEVRVFK KVRSERLEAQ LRGKHIRLYV AAEPLAYERD KLLFTTPVAH LHEEILRYDG
     LCRHQKICQL LNTFPVKVVT ASRHELNCKK LVEMMEQHDR GSDAKKSIMK FLLNVSDSKS
     RIGIEDSVES FLQDLTPSLV DQNRLLPARG PGGPGVVGPG GAVVGGPAGH VGLLPPPPGP
     AAPERDIRDL FKKQVIKCLE EQIQSQVDEI QDLRTLNQTW ENRVRELRDL LTRYASRRED
     SMSLGARDAE LYHLPVLEAV RKARDAAPFR PLAVEDNRLV ANSFFSQFVP GTESLERFLT
     QLWENEYFRT FRLRRLVTHQ GAEEAIVYSN YTVERVTLPY LCHILALGTL DPVPEAYLQL
     SFGEIVAAAY DDSKFCRYVE LICSREKARR RQMSREAAGG VPERGTASSG GPGTLERSAP
     RRLITADEER RGPERVGRFR NGGPDDPRRA GGPYGFH