ID   PORTL_HCMVM             Reviewed;         697 AA.
AC   F5HBR4;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Portal protein {ECO:0000255|HAMAP-Rule:MF_04012};
GN   Name=UL104;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Forms a portal in the viral capsid through which viral DNA is
CC       translocated during DNA packaging. Assembles as a dodecamer at a single
CC       fivefold axe of the T=16 icosahedric capsid. Binds to the molecular
CC       motor that translocates the viral DNA, termed terminase.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBUNIT: Homododecamerizes. Interacts with terminase subunits TRM1 and
CC       TRM3. {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04012}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SIMILARITY: Belongs to the herpesviridae portal protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
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DR   EMBL; AY446894; AAR31654.1; -; Genomic_DNA.
DR   RefSeq; YP_081550.1; NC_006273.2.
DR   SMR; F5HBR4; -.
DR   PRIDE; F5HBR4; -.
DR   GeneID; 3077547; -.
DR   KEGG; vg:3077547; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; TAS:Reactome.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04012; HSV_PORTL; 1.
DR   InterPro; IPR002660; Herpes_Portal.
DR   Pfam; PF01763; Herpes_UL6; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Host nucleus; Reference proteome; Viral genome packaging;
KW   Viral release from host cell; Virion.
FT   CHAIN           1..697
FT                   /note="Portal protein"
FT                   /id="PRO_0000418268"
FT   REGION          633..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        661..685
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   697 AA;  78535 MW;  D166B32C875E321A CRC64;
     MERNHWNEKS SGAKRSRERD LTLSTIRSIL AADERLRIKA SSYLGVGRGV DDEAVIDIFP
     TGQTMSFLRL LHGFLGTCRG QSMHQVLRDP CVLRKQLLYG VCKTLFDTIT VRRVAEEWKL
     HAALFPYRAL DEEDLEQYLL VWSASLRQSV QTGVLGALRD ILYQYADNDD YGLYVDWCVT
     VGLVPLLDVK TKPSEAAERA QFVRAAVQRA TETHPLAQDL LQANLALLLQ VAERLGAVRI
     ANAPEVRVFK KVRSERLEAQ LRGKHIRLYV AAEPLAYERD KLLFTTPVAH LHEEILRYDG
     LCRHQKICQL LNTFPVKVVT ASRHELNCKK LVEMMEQHDR GSDAKKSIMK FLLNVSDSKS
     RIGIEDSVES FLQDLTPSLV DQNRLLPARG PGGPGVVGPG GAVVGGPAGH VGLLPPPPGP
     AAPERDIRDL FKKQVIKCLE EQIQSQVDEI QDLRTLNQTW ENRVRELRDL LTRYASRRED
     SMSLGARDAE LYHLPVLEAV RKARDAAPFR PLAVEDNRLV ANSFFSQFVP GTESLERFLT
     QLWENEYFRT FRLRRLVTHQ GAEEAIVYSN YTVERVTLPY LCHILALGTL DPVPEAYLQL
     SFGEIVAAAY DDSKFCRYVE LICSREKARR RQMSREAAGG VPERGTASSG GPGTLERSAP
     RRLITADEER RGPERVGRFR NGGPDDPRRA GGPYGFH