ID   PORTL_HHV2H             Reviewed;         678 AA.
AC   P89429;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Portal protein {ECO:0000255|HAMAP-Rule:MF_04012};
GN   Name=UL6;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA   Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT   "The genome sequence of herpes simplex virus type 2.";
RL   J. Virol. 72:2010-2021(1998).
CC   -!- FUNCTION: Forms a portal in the viral capsid through which viral DNA is
CC       translocated during DNA packaging. Assembles as a dodecamer at a single
CC       fivefold axe of the T=16 icosahedric capsid. Binds to the molecular
CC       motor that translocates the viral DNA, termed terminase.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBUNIT: Homododecamerizes. Interacts with terminase subunits TRM1 and
CC       TRM3. {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04012}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SIMILARITY: Belongs to the herpesviridae portal protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
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DR   EMBL; Z86099; CAB06766.1; -; Genomic_DNA.
DR   SMR; P89429; -.
DR   PRIDE; P89429; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044423; C:virion component; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04012; HSV_PORTL; 1.
DR   InterPro; IPR002660; Herpes_Portal.
DR   Pfam; PF01763; Herpes_UL6; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Host nucleus; Reference proteome; Viral genome packaging;
KW   Viral release from host cell; Virion.
FT   CHAIN           1..678
FT                   /note="Portal protein"
FT                   /id="PRO_0000115904"
FT   REGION          376..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..443
FT                   /note="Putative leucine zipper motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04012"
FT   REGION          459..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          622..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        664..678
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        166
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04012"
FT   DISULFID        254
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04012"
SQ   SEQUENCE   678 AA;  74902 MW;  B2974CA22AADB1F4 CRC64;
     MAAQRARAPA MRTRGGDAAL CAPEDGWVKV HPTPGTMLFR EILLGQMGYT EGQGVYNVVR
     SSEAATRQLQ AAIFHALLNA TTYRDLEEDW RRHVVARGLQ PQRLVRRYRN AREGDIAGVA
     ERVFDTWRCT LRTTLLDFAH GVVDCFAPGG PSGPTSFPKY IDWLTCLGLV PILRKTREGE
     ATQRLGAFLR QHTLPRQLAT VAGAAERAGP GLLDLAVAFD STRMAEYDRV HIYYNHRRGE
     WLVRDPVSGQ RGECLVLCPP LWTGDRLVFD SPVQRLCPEI VACHALREHA HICRLRNTAS
     VKVLLGRKSD SERGVAGAAR VVNKALGEDD ETKAGSAASR LVRLIINMKG MRHVGDINDT
     VRAYLDEAGG HLIDTPAVDH TLPGFGKGGT GRGSRPQDPG ARPQQLRQAF QTAVVNNING
     MLEGYINNLF GTIERLRETN AGLATQLQAR DRELRRAQAG ALEREQRAAD RAAGGGAGRP
     AEADLLRADY DIIDVSKSMD DDTYVANSFQ HQYIPAYGQD LERLSRLWEH ELVRCFKILR
     HRNKQGQETS ISYSSGAIAS FVAPYFEYVL RAPRAGALIT GSDVILGEEE LWEAVFKKTR
     LQTYLTDVAA LFVADVQHAA LPRPPSPTPA DFRASASPRG GSRSRTRTRS RSPGRTPRGA
     PDQGWGVERR DGRPHARR