ID   PORTL_HHV6U             Reviewed;         662 AA.
AC   P52453;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Portal protein {ECO:0000255|HAMAP-Rule:MF_04012};
GN   Name=U76; Synonyms=HDLF1;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7941342; DOI=10.1006/viro.1994.1589;
RA   Nicholas J.;
RT   "Nucleotide sequence analysis of a 21-kbp region of the genome of human
RT   herpesvirus-6 containing homologues of human cytomegalovirus major
RT   immediate-early and replication genes.";
RL   Virology 204:738-750(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Forms a portal in the viral capsid through which viral DNA is
CC       translocated during DNA packaging. Assembles as a dodecamer at a single
CC       fivefold axe of the T=16 icosahedric capsid. Binds to the molecular
CC       motor that translocates the viral DNA, termed terminase.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBUNIT: Homododecamerizes. Interacts with terminase subunits TRM1 and
CC       TRM3. {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04012}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SIMILARITY: Belongs to the herpesviridae portal protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
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DR   EMBL; U13194; AAA68467.1; -; Genomic_DNA.
DR   EMBL; X83413; CAA58368.1; -; Genomic_DNA.
DR   RefSeq; NP_042969.2; NC_001664.2.
DR   SMR; P52453; -.
DR   PRIDE; P52453; -.
DR   DNASU; 1487958; -.
DR   GeneID; 1487958; -.
DR   KEGG; vg:1487958; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044423; C:virion component; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04012; HSV_PORTL; 1.
DR   InterPro; IPR002660; Herpes_Portal.
DR   Pfam; PF01763; Herpes_UL6; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome; Viral genome packaging;
KW   Viral release from host cell; Virion.
FT   CHAIN           1..662
FT                   /note="Portal protein"
FT                   /id="PRO_0000115907"
SQ   SEQUENCE   662 AA;  77235 MW;  95D555757B3A7F99 CRC64;
     MHRASANSLL NSVSGSMMWR NQSSGRRPSK RLSDNEATLS TINSILGAED MLSKNLLSYL
     PPNNEEIDMI YPSEQIMTFI EMLHGHKNFF KGQTIHNALR DSAVLKKQIA YGVAQALLNS
     VSIQQIHDEW KRHVRSFPFH NKKLSFQDYF SVWAHAIKQV ILGDISNIIN FILQSIDNSH
     YNRYVDWICT VGIVPFMRTT HTAPNLYNLL QQVSSKLIHD IVRHKQNIVT PVLLGLSSVI
     IPDFHNIKIF RDRNSEQISC FKNKKAIAFF TYSTPYVIRN RLMLTTPLAH LSPELKKHNS
     LRRHQKMCQL LNTFPIKVLT TAKTDVTNKK IMDMIEKEEK SSDAKKSLIK FLLNLSDSKS
     KIGIRDSVEG FIQEITPSII DQNKLMLNRG QFRKRSAIDT GERDVRDLFK KQIIKCMEEQ
     IQTQMDEIET LKTTNQMFER KIKDLHSLLE TNNDCDRYNP NLDHDLENLS LSRALNIVQR
     LPFTSVSIDD TRSVANSFFS QYIPDTQYAD KRIDQLWEME YMRTFRLRKN VNNQGQEESI
     TYSNYSIELL IVPFLRRFLN IYNLESIPEE FLFLSLGEIL LAIYESSKIK HYLRLVYVRE
     LNQISEVFNL TQTHPENSEP IFDSNIFSPN PENEILEKIK RIRNLRRIQH LTRPNYPKGD
     QD