ID   PORTL_HHV6Z             Reviewed;         662 AA.
AC   P52454;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Portal protein {ECO:0000255|HAMAP-Rule:MF_04012};
GN   Name=U76; Synonyms=CB3L;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8634027; DOI=10.1007/bf01718406;
RA   Lindquester G.J., Inoue N., Allen R.D., Castelli J.W., Stamey F.R.,
RA   Dambaugh T.R., O'Brian J.J., Danovich R.M., Frenkel N., Pellett P.E.;
RT   "Restriction endonuclease mapping and molecular cloning of the human
RT   herpesvirus 6 variant B strain Z29 genome.";
RL   Arch. Virol. 141:367-379(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- FUNCTION: Forms a portal in the viral capsid through which viral DNA is
CC       translocated during DNA packaging. Assembles as a dodecamer at a single
CC       fivefold axe of the T=16 icosahedric capsid. Binds to the molecular
CC       motor that translocates the viral DNA, termed terminase.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBUNIT: Homododecamerizes. Interacts with terminase subunits TRM1 and
CC       TRM3. {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04012}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SIMILARITY: Belongs to the herpesviridae portal protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
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DR   EMBL; AF157706; AAB06359.1; -; Genomic_DNA.
DR   PIR; T44221; T44221.
DR   RefSeq; NP_050255.1; NC_000898.1.
DR   SMR; P52454; -.
DR   PRIDE; P52454; -.
DR   DNASU; 1497076; -.
DR   GeneID; 1497076; -.
DR   KEGG; vg:1497076; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044423; C:virion component; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04012; HSV_PORTL; 1.
DR   InterPro; IPR002660; Herpes_Portal.
DR   Pfam; PF01763; Herpes_UL6; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome; Viral genome packaging;
KW   Viral release from host cell; Virion.
FT   CHAIN           1..662
FT                   /note="Portal protein"
FT                   /id="PRO_0000115908"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   662 AA;  77200 MW;  5126392A37C67B90 CRC64;
     MHRASANSPL NSVSGSMMWR NQSSGRRPSK RLSDNEATLS TINSILGAED MLSKNLLSYL
     PPNNEEIDMI YPSEQIMTFI EMLHGHKNFF KGQTIHNALR DSAVLKKQIA YGVAQALLNS
     VSIQQIHDEW KRHVRSFPFH NKKLSFQDYF SVWAHAIKQV ILGDISNIIN FILQSIDNSH
     YNRYVDWICT VGIVPFMRTT PTAPNLYNLL QQVSSKLIHD IVRHKQNIVT PILLGLSSVI
     IPDFHNIKIF RDRNSEQISC FKNKKAIAFF TYSTPYVIRN RLMLTTPLAH LSPELKKHNS
     LRRHQKMCQL LNTFPIKVLT AAKTDVTNKK IMDMIEKEEK NSDAKKSLIK FLLNLSDSKS
     KIGIRDSVEG FIQEITPSII DQNKLMLNRG QFRKRSAIDT GERDVRDLFK KQIIKCMEEQ
     IQTQMDEIET LKTTNQMFER KIKDLHSLLE TNNDCDRYNP DLDHDLENLS LSRALNIVQR
     LPFTSVSIDD TRSVANSFFS QYIPDTQYAD KRIDQLWEME YMRTFRLRKN VNNQGQEESI
     TYSNYSIELL IVPFLRRLLN IYNLESIPEE FLFLSLGEIL LAIYESSKIK HYLRLVYVRE
     LNQISEVYNL TQTHPENNEP IFDSNIFSPN PENEILEKIK RIRNLRRIQH LTRPNYPKGD
     QD