ID   PORTL_HHV7J             Reviewed;         640 AA.
AC   P52455;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Portal protein {ECO:0000255|HAMAP-Rule:MF_04012};
GN   Name=U76;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Forms a portal in the viral capsid through which viral DNA is
CC       translocated during DNA packaging. Assembles as a dodecamer at a single
CC       fivefold axe of the T=16 icosahedric capsid. Binds to the molecular
CC       motor that translocates the viral DNA, termed terminase.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBUNIT: Homododecamerizes. Interacts with terminase subunits TRM1 and
CC       TRM3. {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04012}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04012}.
CC   -!- SIMILARITY: Belongs to the herpesviridae portal protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04012}.
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DR   EMBL; U43400; AAC54737.1; -; Genomic_DNA.
DR   PIR; T41977; T41977.
DR   SMR; P52455; -.
DR   PRIDE; P52455; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044423; C:virion component; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04012; HSV_PORTL; 1.
DR   InterPro; IPR002660; Herpes_Portal.
DR   Pfam; PF01763; Herpes_UL6; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome; Viral genome packaging;
KW   Viral release from host cell; Virion.
FT   CHAIN           1..640
FT                   /note="Portal protein"
FT                   /id="PRO_0000115909"
SQ   SEQUENCE   640 AA;  74539 MW;  4021A6E1B453FB63 CRC64;
     MLRNQSVGNG VSKQASAKAA TFSTINSTLA ADDMFKRNFV SYLPLNNEDN DILFPSIKTI
     KFIEMLHGKK EFFKGQSIHS VLRDSAVFKK QMFYTLSHTL LNSISIQQIN AEWQRHLKAF
     PFRSKGMSFQ EYFNIWYYAI KQVILEGILQ TINYILQNLD NDIYNKYIDW ICTIGITPIV
     TLPKNKVTLT PLAKSISSRL IQEIIRNKQN FLLHILTQIS STSIADFTNI NIYRNKSDGN
     ITCLSNNKEL EYFVYSAPYF INNQLLFTTP LAHLYSELNK HENLHRHRKM CQLLNTFPIK
     VLTTSKNSVD NKKILELIER EEKTSDAKKS LIKFLLNLSD SKSKIGITDS IEGFLQDITP
     SIIDQNKLLI SKGNLQRRGQ DNNDRDIRDI FKKQIIKCME EQIQSQLDEI ETLKTANRLF
     ENKIKDMHSL INLSETSKHD FTLDSDIESL SLAKALNKVQ SLPFTSVSID DTRAVANSFF
     SQYIPDIEYA DKKIDQLWET EYTRTFRLRK NVNNQGQEDS ISYSNYTLEL LLIPFMKHVL
     KLRHFELLPE EFLFLSLKEI MLAVYSNCKI KHYLRLIYIR QINELSHLIH TQKQSDLTLT
     PDLGSTNPED FQYPQDDVAS KLKRIRNSRH IQYIKRPEYL