ID   POR_GLUOX               Reviewed;         485 AA.
AC   P80354; Q5FR14;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Polyol:NADP oxidoreductase;
DE            EC=1.1.1.-;
GN   Name=por; OrderedLocusNames=GOX1432;
OS   Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Gluconobacter.
OX   NCBI_TaxID=290633;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=621H;
RX   PubMed=15665824; DOI=10.1038/nbt1062;
RA   Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F.,
RA   Ehrenreich A., Gottschalk G., Deppenmeier U.;
RT   "Complete genome sequence of the acetic acid bacterium Gluconobacter
RT   oxydans.";
RL   Nat. Biotechnol. 23:195-200(2005).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-50.
RC   STRAIN=DSM 350;
RA   Klasen R.;
RL   Thesis (1994), Heinrich-Heine University / Duesseldorf, Germany.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000009; AAW61182.1; -; Genomic_DNA.
DR   RefSeq; WP_011252969.1; NZ_LT900338.1.
DR   AlphaFoldDB; P80354; -.
DR   SMR; P80354; -.
DR   STRING; 290633.GOX1432; -.
DR   EnsemblBacteria; AAW61182; AAW61182; GOX1432.
DR   KEGG; gox:GOX1432; -.
DR   eggNOG; COG0246; Bacteria.
DR   HOGENOM; CLU_027324_0_1_5; -.
DR   OMA; GETFIQW; -.
DR   Proteomes; UP000006375; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR000669; Mannitol_DH.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..485
FT                   /note="Polyol:NADP oxidoreductase"
FT                   /id="PRO_0000058525"
FT   CONFLICT        50
FT                   /note="E -> F (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   485 AA;  53618 MW;  3601397B4BDCC26D CRC64;
     MITRETLKSL PANVQAPPYD IDGIKPGIVH FGVGNFFRAH EAFYVEQILE HAPDWAIVGV
     GLTGSDRSKK KAEEFKAQDC LYSLTETAPS GKSTVRVMGA LRDYLLAPAD PEAVLKHLVD
     PAIRIVSMTI TEGGYNINET TGAFDLENAA VKADLQNPEK PSTVFGYVVE ALRRRRDAGG
     KAFTVMSCDN LRHNGNVARK AFLGYAKARD PELAKWIEEN ATFPNGMVDR ITPTVSAEIA
     KKLNAASGLD DDLPLVAEDF HQWVLEDRFA NGRPPLEKAG VQLVDDVTDW EHVKIRMLNA
     GHITLCFPGI LVGYENVDDA IEDKDLRGNL ENYLNKDVIP TLKAPPGMTL EGYRDSVISR
     FSNKAMSDQT LRIASDGCSK IQVFWTETVR RAIECKRDLS RIAFGIASYL EMLRGRDEKG
     GTYESSEPTY GEAQKKLAKA DDFESALKLP AFDGWRDLDT SELDQKVIAL RKVIREKGVK
     AAIPA