ID   POST_XENLA              Reviewed;         555 AA.
AC   P27536;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Posterior protein;
DE            Short=xPO;
GN   Name=po; Synonyms=post.2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   INDUCTION.
RC   TISSUE=Neurula;
RX   PubMed=1718676; DOI=10.1242/dev.112.3.747;
RA   Sato S.M., Sargent T.D.;
RT   "Localized and inducible expression of Xenopus-posterior (Xpo), a novel
RT   gene active in early frog embryos, encoding a protein with a 'CCHC' finger
RT   domain.";
RL   Development 112:747-753(1991).
RN   [2]
RP   INDUCTION.
RX   PubMed=8618860; DOI=10.1073/pnas.92.26.12141;
RA   Re'em-Kalma Y., Lamb T., Frank D.;
RT   "Competition between noggin and bone morphogenetic protein 4 activities may
RT   regulate dorsalization during Xenopus development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:12141-12145(1995).
RN   [3]
RP   INDUCTION.
RX   PubMed=8946920; DOI=10.1101/gad.10.21.2805;
RA   Hoppler S., Brown J.D., Moon R.T.;
RT   "Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus
RT   embryos.";
RL   Genes Dev. 10:2805-2817(1996).
CC   -!- FUNCTION: This protein is expressed exclusively in posterior mesoderm
CC       and ectoderm of early embryos suggesting a possible role in
CC       organization of anteroposterior axis.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously throughout the embryo at
CC       early stages. By mid-gastrula (stage 11), expression is concentrated in
CC       the mesoderm and ectoderm surrounding the yolk plug, being strongest in
CC       posterior dorsal mesoderm. At stage 13, also expressed at a low level
CC       in the pre-cement gland. At mid to late tailbud stages, highly
CC       localized in mesoderm and ectoderm derivatives in the extreme posterior
CC       of the tail. {ECO:0000269|PubMed:1718676}.
CC   -!- DEVELOPMENTAL STAGE: Expressed zygotically shortly after the
CC       midblastula transition (MBT). Expression remains constant till
CC       gastrulation then rapidly and transiently increases to peak during
CC       neurulation. Expression disappears by tailbud stages.
CC       {ECO:0000269|PubMed:1718676}.
CC   -!- INDUCTION: By growth factors such as FGF and TFG-beta. By Wnt-signaling
CC       and BMP-signaling. {ECO:0000269|PubMed:1718676,
CC       ECO:0000269|PubMed:8618860, ECO:0000269|PubMed:8946920}.
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DR   EMBL; X58487; CAA41397.1; -; mRNA.
DR   PIR; A43784; A43784.
DR   RefSeq; NP_001095251.1; NM_001101781.1.
DR   AlphaFoldDB; P27536; -.
DR   SMR; P27536; -.
DR   GeneID; 397964; -.
DR   KEGG; xla:397964; -.
DR   CTD; 397964; -.
DR   OrthoDB; 1670557at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 397964; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   Pfam; PF00098; zf-CCHC; 1.
DR   SMART; SM00343; ZnF_C2HC; 1.
DR   SUPFAM; SSF57756; SSF57756; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Metal-binding; Reference proteome;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..555
FT                   /note="Posterior protein"
FT                   /id="PRO_0000058526"
FT   ZN_FING         413..430
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   REGION          455..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        458..487
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..502
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   555 AA;  63667 MW;  3E6D394FDBDF9AD8 CRC64;
     MEFVERYVNK YASADYHSCA DESVTHQFKS LLTQCQRYNN KVKCNHLAKM VKKIKMANEI
     LALLKMKVIA ENKAEQWRNE KVQFREDLEK FGESLIVAAS TSEEHISELE ELREKVELLA
     KQNDLLEEKL KDCEERCRLR EQEVISLESK AGYELNVPVS VCPVTEQEIK DGEQGIRPQT
     LPSPTLFSPQ SECARQRINN TYVPTDNNIH SNSALKIQEV ISLTQILGKF DTNLSPISLY
     NKLEAVVKQY NLGNKDACAL LRAWLPYQLA AELRPPVGKH IGTLSNINEN WGSTSERLRE
     LQRILGGRDI RGTNALENAR YRKGDDPMLF CTDYLSLYKV VFNCPDMLPD EPNFLYSMAN
     KCNVDYNTRT ALRYATSYNN FINTLRDWSQ ESFEFQRHIS VAYKKKQSRR FPRKCYSCGK
     YGHIARFCRT SANQHDTYPI HSIQRQEGDA QENLNDYLLD HSPPSETETV VSSDNIDTGS
     NSAGDQKESQ NEPKREFHTP PCKTGKEGTT APPFIPWVNI PLWLYSSWSH IAMLMLMDNI
     AQFAQGVPNT NMPVF