POT12_ARATH
ID POT12_ARATH Reviewed; 827 AA.
AC O80739;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Putative potassium transporter 12;
DE Short=AtPOT12;
GN Name=POT12; Synonyms=KUP12; OrderedLocusNames=At1g60160; ORFNames=T13D8.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- FUNCTION: Putative potassium transporter.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC24049.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004473; AAC24049.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33663.1; -; Genomic_DNA.
DR PIR; T02268; T02268.
DR RefSeq; NP_176222.2; NM_104706.5.
DR AlphaFoldDB; O80739; -.
DR BioGRID; 27536; 2.
DR IntAct; O80739; 2.
DR STRING; 3702.AT1G60160.1; -.
DR iPTMnet; O80739; -.
DR PaxDb; O80739; -.
DR PRIDE; O80739; -.
DR ProteomicsDB; 250519; -.
DR EnsemblPlants; AT1G60160.1; AT1G60160.1; AT1G60160.
DR GeneID; 842311; -.
DR Gramene; AT1G60160.1; AT1G60160.1; AT1G60160.
DR KEGG; ath:AT1G60160; -.
DR Araport; AT1G60160; -.
DR TAIR; locus:2195688; AT1G60160.
DR eggNOG; ENOG502QPSA; Eukaryota.
DR HOGENOM; CLU_008142_2_0_1; -.
DR InParanoid; O80739; -.
DR OMA; LMIMCIV; -.
DR OrthoDB; 332035at2759; -.
DR PhylomeDB; O80739; -.
DR PRO; PR:O80739; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O80739; baseline and differential.
DR Genevisible; O80739; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0048825; P:cotyledon development; IMP:TAIR.
DR GO; GO:0006813; P:potassium ion transport; IBA:GO_Central.
DR InterPro; IPR003855; K+_transporter.
DR PANTHER; PTHR30540; PTHR30540; 1.
DR Pfam; PF02705; K_trans; 1.
DR TIGRFAMs; TIGR00794; kup; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..827
FT /note="Putative potassium transporter 12"
FT /id="PRO_0000209088"
FT TOPO_DOM 1..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..129
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..216
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..253
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..335
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..363
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 385..402
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..454
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 476..480
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 523..536
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 537..557
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 558..827
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 92088 MW; C6C9F642B8219D1D CRC64;
MEEIEEGSSN NSIRRVGTGS SDRRWVDGSE VDSETPLFSE IRDRDYSFGN LRRRLMKKPK
RADSLDVEAM EIAGSHGHNL KDLSLLTTLG IAFQTLGVVY GDMGTSPLYV FSDVFSKVPI
RSEVDVLGAL SLVIYTIAVI PLAKYVFVVL KANDNGEGGT FALYSLICRY AKVNKLPNQQ
PADEQISSFR LKLPTPELER ALGIKEALET KGYLKTLLLL LVLMGTSMII GDGILTPAMS
VMSAMSGLQG EVKGFGTNAL VMSSIVILVA LFSIQRFGTG KVGFLFAPVL ALWFFSLGAI
GIYNLLKYDF TVIRALNPFY IVLFFNKNSK QAWSALGGCV LCITGAEAMF ADLGHFSVRS
IQMAFTCVVF PCLLLAYMGQ AAYLTKHPEA SARIFYDSVP KSLFWPVFVI ATLAAMIASQ
AMISATFSCV KQAMALGCFP RLKIIHTSKK RIGQIYIPVI NWFLMIMCIL VVSIFRSTTH
IANAYGIAEV GVMMVSTVLV TLVMLLIWQT NIFLALCFPL IFGSVETIYL LAVLTKILEG
GWVPLVFATF FLTVMYIWNY GSVLKYQSEV RERISMDFMR ELGSTLGTIR IPGIGLLYNE
LVQGIPSIFG QFLLTLPAIH STIIFVCIKY VPVPVVPQEE RFLFRRVCPK DYHMFRCIAR
YGYKDVRKED SRVFEQLLIE SLEKFLRCEA LEDALESTLN DFDPDRVSVA SDTYTDDLMA
PLIHRAKRSE PEQELDSEVL PSSSVGSSME EDPALEYELA ALREATDSGL TYLLAHGDVR
AKKNSIFVKK LVINYFYAFL RRNCRAGAAN LTVPHMNILQ AGMTYMV
