POT1C_ARATH
ID POT1C_ARATH Reviewed; 144 AA.
AC A9JTY4;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Protection of telomeres protein 1c {ECO:0000303|PubMed:31134349};
DE Short=AtPOT1c {ECO:0000303|PubMed:31134349};
DE AltName: Full=Protection of telomeres protein 3 {ECO:0000305};
GN Name=POT1C {ECO:0000303|PubMed:31134349};
GN OrderedLocusNames=At2g04395 {ECO:0000312|Araport:AT2G04395}; ORFNames=T1O3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-113.
RC STRAIN=cv. Columbia;
RX PubMed=12481096; DOI=10.1104/pp.010207;
RA Xiao Y.-L., Malik M., Whitelaw C.A., Town C.D.;
RT "Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2
RT of Arabidopsis.";
RL Plant Physiol. 130:2118-2128(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=17911168; DOI=10.1242/jcs.004119;
RA Rossignol P., Collier S., Bush M., Shaw P., Doonan J.H.;
RT "Arabidopsis POT1A interacts with TERT-V(I8), an N-terminal splicing
RT variant of telomerase.";
RL J. Cell Sci. 120:3678-3687(2007).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF
RP TYR-65.
RX PubMed=31134349; DOI=10.1007/s00299-019-02427-9;
RA Kobayashi C.R., Castillo-Gonzalez C., Survotseva Y., Canal E.,
RA Nelson A.D.L., Shippen D.E.;
RT "Recent emergence and extinction of the protection of telomeres 1c gene in
RT Arabidopsis thaliana.";
RL Plant Cell Rep. 38:1081-1097(2019).
CC -!- FUNCTION: Binds specifically single-stranded telomeric DNA with weak
CC affinity (PubMed:31134349). Has probably no function in the regulation
CC of telomere length (PubMed:31134349). {ECO:0000269|PubMed:31134349}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q56Y52}.
CC Chromosome, telomere {ECO:0000250|UniProtKB:Q56Y52}.
CC -!- TISSUE SPECIFICITY: Expressed at extremely low levels at the limit of
CC detection. {ECO:0000269|PubMed:31134349}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:31134349}.
CC -!- MISCELLANEOUS: POT1C is a highly divergent POT1 gene, which harbors
CC multiple deletions within its gene body, and insertions of transposable
CC elements within its promoter that probably silence permanentely the
CC gene (PubMed:31134349). Therefore, it is probably a non-functional gene
CC (PubMed:31134349). {ECO:0000269|PubMed:31134349}.
CC -!- SIMILARITY: Belongs to the telombin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAL36192.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AC006951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002685; AEC05830.2; -; Genomic_DNA.
DR EMBL; AY464640; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BN000975; CAL36192.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001318197.1; NM_001335231.1.
DR AlphaFoldDB; A9JTY4; -.
DR SMR; A9JTY4; -.
DR STRING; 3702.AT2G04395.1; -.
DR PRIDE; A9JTY4; -.
DR EnsemblPlants; AT2G04395.1; AT2G04395.1; AT2G04395.
DR GeneID; 814979; -.
DR Gramene; AT2G04395.1; AT2G04395.1; AT2G04395.
DR KEGG; ath:AT2G04395; -.
DR Araport; AT2G04395; -.
DR eggNOG; KOG4757; Eukaryota.
DR HOGENOM; CLU_1671733_0_0_1; -.
DR OrthoDB; 940962at2759; -.
DR PRO; PR:A9JTY4; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; A9JTY4; baseline and differential.
DR GO; GO:0000783; C:nuclear telomere cap complex; IBA:GO_Central.
DR GO; GO:0098505; F:G-rich strand telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0010521; F:telomerase inhibitor activity; IBA:GO_Central.
DR GO; GO:0051974; P:negative regulation of telomerase activity; IBA:GO_Central.
DR GO; GO:0032210; P:regulation of telomere maintenance via telomerase; IBA:GO_Central.
DR GO; GO:0016233; P:telomere capping; IBA:GO_Central.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR028389; POT1.
DR InterPro; IPR011564; Telomer_end-bd_POT1/Cdc13.
DR PANTHER; PTHR14513; PTHR14513; 2.
DR Pfam; PF02765; POT1; 1.
DR SMART; SM00976; Telo_bind; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
PE 1: Evidence at protein level;
KW Chromosome; DNA-binding; Nucleus; Reference proteome; Telomere.
FT CHAIN 1..144
FT /note="Protection of telomeres protein 1c"
FT /id="PRO_0000416959"
FT MUTAGEN 65
FT /note="Y->F: No effect on affinity binding to single-
FT stranded telomeric DNA."
FT /evidence="ECO:0000269|PubMed:31134349"
FT CONFLICT 6
FT /note="D -> E (in Ref. 3; AY464640)"
FT /evidence="ECO:0000305"
FT CONFLICT 23
FT /note="E -> Q (in Ref. 3; AY464640)"
FT /evidence="ECO:0000305"
FT CONFLICT 65..67
FT /note="YSR -> FSK (in Ref. 3; AY464640)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="M -> I (in Ref. 3; AY464640)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="K -> E (in Ref. 3; AY464640)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 144 AA; 16333 MW; 5F381702723FFB9A CRC64;
MAKKRDSPKL IKIKDAIKLI NQEVSLIGIV LEQREPKQCR NNDWICTLRI IDDTYPSPGL
TVNVYSRTLE QLPQIKNHDD MILFTRIKMQ TFDSGKRVNA ACSRWVSSFA LFEGEDLILH
ADEDTSAVFV WDGTDAPPAS ILAK
