ID   POT2_CAEEL              Reviewed;         251 AA.
AC   O45595;
DT   13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Protection of telomeres homolog 2 {ECO:0000305};
GN   Name=pot-2 {ECO:0000312|WormBase:F57C2.3};
GN   Synonyms=CeOB1 {ECO:0000303|PubMed:18329362};
GN   ORFNames=F57C2.3 {ECO:0000312|WormBase:F57C2.3};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=18329362; DOI=10.1016/j.cell.2007.12.039;
RA   Raices M., Verdun R.E., Compton S.A., Haggblom C.I., Griffith J.D.,
RA   Dillin A., Karlseder J.;
RT   "C. elegans telomeres contain G-strand and C-strand overhangs that are
RT   bound by distinct proteins.";
RL   Cell 132:745-757(2008).
RN   [3] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=22547822; DOI=10.1073/pnas.1119191109;
RA   Cheng C., Shtessel L., Brady M.M., Ahmed S.;
RT   "Caenorhabditis elegans POT-2 telomere protein represses a mode of
RT   alternative lengthening of telomeres with normal telomere lengths.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:7805-7810(2012).
RN   [4] {ECO:0000305}
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=23390606; DOI=10.1534/g3.112.004440;
RA   Shtessel L., Lowden M.R., Cheng C., Simon M., Wang K., Ahmed S.;
RT   "Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance
RT   pathways.";
RL   G3 (Bethesda) 3:305-313(2013).
RN   [5] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=24297748; DOI=10.1083/jcb.201307181;
RA   Ferreira H.C., Towbin B.D., Jegou T., Gasser S.M.;
RT   "The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres
RT   through SUN-1 at the nuclear periphery.";
RL   J. Cell Biol. 203:727-735(2013).
CC   -!- FUNCTION: Telomeric DNA-binding protein, which binds to two or more
CC       single-stranded G-rich repeat sequences (G-strand), with high
CC       specificity to the 5'-TTAGGC-3' sequence (PubMed:18329362,
CC       PubMed:23390606). In addition, repeat sequence binding requires a 3'
CC       single-stranded telomeric overhang (PubMed:18329362). Acts redundantly
CC       with pot-1 to negatively regulate telomerase-mediated telomere
CC       extension (PubMed:18329362, PubMed:23390606, PubMed:24297748). Also
CC       regulates telomere length by the telomerase-independent telomere
CC       maintenance pathway called ALT (alternative lengthening of telomeres)
CC       (PubMed:23390606, PubMed:22547822, PubMed:24297748). Does not appear to
CC       have a role in anchoring telomeres to the nuclear envelope
CC       (PubMed:24297748). {ECO:0000269|PubMed:18329362,
CC       ECO:0000269|PubMed:22547822, ECO:0000269|PubMed:23390606,
CC       ECO:0000269|PubMed:24297748}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:18329362,
CC       ECO:0000305|PubMed:23390606}. Chromosome, telomere
CC       {ECO:0000305|PubMed:18329362, ECO:0000305|PubMed:23390606}.
CC   -!- SIMILARITY: Belongs to the telombin family. {ECO:0000305}.
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DR   EMBL; BX284602; CAB05525.1; -; Genomic_DNA.
DR   PIR; T22839; T22839.
DR   RefSeq; NP_497017.1; NM_064616.3.
DR   AlphaFoldDB; O45595; -.
DR   SMR; O45595; -.
DR   STRING; 6239.F57C2.3; -.
DR   EPD; O45595; -.
DR   PaxDb; O45595; -.
DR   PeptideAtlas; O45595; -.
DR   EnsemblMetazoa; F57C2.3.1; F57C2.3.1; WBGene00010195.
DR   GeneID; 175110; -.
DR   KEGG; cel:CELE_F57C2.3; -.
DR   UCSC; F57C2.3; c. elegans.
DR   CTD; 175110; -.
DR   WormBase; F57C2.3; CE16154; WBGene00010195; pot-2.
DR   eggNOG; KOG1361; Eukaryota.
DR   GeneTree; ENSGT00940000158175; -.
DR   HOGENOM; CLU_096926_0_0_1; -.
DR   InParanoid; O45595; -.
DR   OMA; ETINGAQ; -.
DR   PhylomeDB; O45595; -.
DR   PRO; PR:O45595; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00010195; Expressed in germ line (C elegans) and 3 other tissues.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; ISS:WormBase.
DR   GO; GO:1904357; P:negative regulation of telomere maintenance via telomere lengthening; IMP:WormBase.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR032042; POT1PC.
DR   Pfam; PF16686; POT1PC; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..251
FT                   /note="Protection of telomeres homolog 2"
FT                   /id="PRO_0000448581"
FT   REGION          221..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   251 AA;  28987 MW;  8F2F231D01C38B9F CRC64;
     MSSFDRRIEA ACKFDDERYY KQYHRYFDVL AQVHSVVETI NGAQMLRVWR GRKFGPGASA
     ERRERRLFHV TQDSFKRYIV PPNPRIGKAI EENGKELLIE IDVYDDHRDG LKNLNSGDFV
     AIQNVHAAST RQTEMQVLHG GGASYQRGIT TVPVDFEHEA FQNFKKKVEA VLETVAYDEN
     FTEFQQPEEV AENHVDEEPQ EEALPRGVVL RTETCDFMDM ELDNWPEGPP KTFAEAIARA
     NNSRRPRDPP Q