POT6_ARATH
ID POT6_ARATH Reviewed; 782 AA.
AC Q8W4I4; O64607; Q9M7K0;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Potassium transporter 6;
DE Short=AtHAK6;
DE Short=AtPOT6;
GN Name=POT6; Synonyms=HAK6, KUP6; OrderedLocusNames=At1g70300;
GN ORFNames=F17O7.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 89-293.
RC STRAIN=cv. Columbia;
RA Rubio F., Santa-Maria G.E., Rodriguez-Navarro A.;
RT "Cloning of Arabidopsis and barley cDNAs encoding HAK potassium
RT transporters in root and shoot cells.";
RL Physiol. Plantarum 109:34-43(2000).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: Probable potassium transporter.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC18809.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC003671; AAC18809.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35043.1; -; Genomic_DNA.
DR EMBL; AY062542; AAL32620.1; -; mRNA.
DR EMBL; AY093328; AAM13327.1; -; mRNA.
DR EMBL; AF129482; AAF36494.1; -; mRNA.
DR PIR; T01493; T01493.
DR RefSeq; NP_177187.2; NM_105698.5.
DR AlphaFoldDB; Q8W4I4; -.
DR BioGRID; 28586; 13.
DR IntAct; Q8W4I4; 12.
DR STRING; 3702.AT1G70300.1; -.
DR PaxDb; Q8W4I4; -.
DR PRIDE; Q8W4I4; -.
DR ProteomicsDB; 250608; -.
DR EnsemblPlants; AT1G70300.1; AT1G70300.1; AT1G70300.
DR GeneID; 843366; -.
DR Gramene; AT1G70300.1; AT1G70300.1; AT1G70300.
DR KEGG; ath:AT1G70300; -.
DR Araport; AT1G70300; -.
DR TAIR; locus:2016139; AT1G70300.
DR eggNOG; ENOG502QPSA; Eukaryota.
DR HOGENOM; CLU_008142_2_0_1; -.
DR InParanoid; Q8W4I4; -.
DR OMA; YMQGIED; -.
DR OrthoDB; 332035at2759; -.
DR PhylomeDB; Q8W4I4; -.
DR PRO; PR:Q8W4I4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8W4I4; baseline and differential.
DR Genevisible; Q8W4I4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006813; P:potassium ion transport; IBA:GO_Central.
DR InterPro; IPR003855; K+_transporter.
DR PANTHER; PTHR30540; PTHR30540; 1.
DR Pfam; PF02705; K_trans; 1.
DR TIGRFAMs; TIGR00794; kup; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..782
FT /note="Potassium transporter 6"
FT /id="PRO_0000209082"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..296
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..347
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..395
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 417..421
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 464..474
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 496..782
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 664..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 106
FT /note="V -> I (in Ref. 4; AAF36494)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="C -> R (in Ref. 4; AAF36494)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="L -> W (in Ref. 4; AAF36494)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="W -> R (in Ref. 4; AAF36494)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 782 AA; 87202 MW; 07047BFEB2050C68 CRC64;
MEIESGSYQN AKKESWRTVL TLAYQSLGVV YGDLSISPLY VYKSTFAEDI HHSESNEEIF
GVLSFIFWTI TLVPLLKYVF IVLRADDNGE GGTFALYSLL CRHARVNSLP SCQLADEQLI
EYKTDSIGSS SMPQSGFAAS LKSTLEKHGV LQKILLVLAL IGTCMVIGDG VLTPAISVFS
AVSGVELSMS KEHHKYIELP AACVILIGLF ALQHYGTHRV GFLFAPVILL WLMCISAIGV
YNIFHWNPHV YQALSPYYMY KFLKKTQSRG WMSLGGILLC ITGSEAMFAD LGHFSQLSIK
IAFTSLVYPS LILAYMGQAA YLSQHHIIES EYNIGFYVSV PERLRWPVLV IAILAAVVGS
QAIITGTFSI IKQCSALGCF PKVKIVHTSS KIHGQIYIPE INWILMVLCL AVTIGFRDTK
RLGNASGLAV ITVMLVTTCL MSLVIVLCWH KSVIFAIVFV VFFGTIESLY FSASLIKFLE
GAWVPIALAF CFLLAMCTWH YGTLKRYEYD VQNKVSVNWL LSLSQTLGIA RVRGLGLIHT
ELVSGVPAIF SHFVTNLPAF HQVLVFLCVK SVPVPHVRPQ ERFLVGRIGP KEFRIYRCIV
RFGYRDVHKD DFEFEGDLVC SIAEFIRTEA ETAATAAETN GEDDDRMSVV GTCSTYMQGI
EDHYESDIDD PDKPGTSEIR SPKPKKKSKS KVKKRVRFVV PETPKIEKET RQELMELTEA
REGGVAYIMG NAYMKAKPGS GLLKRLAINI GYEFLRRNTR GPRNMLTSPH ASTLEVGMIY
NV
