POTB2_HUMAN
ID POTB2_HUMAN Reviewed; 544 AA.
AC H3BUK9;
DT 24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=POTE ankyrin domain family member B2;
GN Name=POTEB2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- SIMILARITY: Belongs to the POTE family. {ECO:0000305}.
CC -!- CAUTION: Maps to a duplicated region on chromosome 15; the gene is
CC present in at least 3 almost identical copies. {ECO:0000305}.
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DR EMBL; AC012414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59248.1; -.
DR RefSeq; NP_001264232.1; NM_001277303.1.
DR RefSeq; NP_001264233.1; NM_001277304.1.
DR AlphaFoldDB; H3BUK9; -.
DR SMR; H3BUK9; -.
DR BioGRID; 3190427; 13.
DR BioGRID; 939060; 5.
DR IntAct; H3BUK9; 4.
DR STRING; 9606.ENSP00000456953; -.
DR iPTMnet; H3BUK9; -.
DR PhosphoSitePlus; H3BUK9; -.
DR BioMuta; POTEB2; -.
DR MassIVE; H3BUK9; -.
DR PaxDb; H3BUK9; -.
DR PRIDE; H3BUK9; -.
DR ProteomicsDB; 42961; -.
DR DNASU; 100287399; -.
DR Ensembl; ENST00000454856.4; ENSP00000456953.1; ENSG00000230031.10.
DR GeneID; 100287399; -.
DR GeneID; 100996331; -.
DR KEGG; hsa:100287399; -.
DR MANE-Select; ENST00000439682.2; ENSP00000457689.2; NM_001277304.2; NP_001264233.1.
DR MANE-Select; ENST00000454856.4; ENSP00000456953.1; NM_001277303.1; NP_001264232.1.
DR UCSC; uc031qqz.2; human.
DR CTD; 100287399; -.
DR DisGeNET; 100996331; -.
DR GeneCards; POTEB2; -.
DR HGNC; HGNC:48327; POTEB2.
DR HPA; ENSG00000230031; Tissue enriched (testis).
DR neXtProt; NX_H3BUK9; -.
DR VEuPathDB; HostDB:ENSG00000230031; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000163068; -.
DR HOGENOM; CLU_000134_9_2_1; -.
DR OMA; NPGNTCD; -.
DR OrthoDB; 711966at2759; -.
DR PhylomeDB; H3BUK9; -.
DR TreeFam; TF337879; -.
DR PathwayCommons; H3BUK9; -.
DR SignaLink; H3BUK9; -.
DR BioGRID-ORCS; 100287399; 13 hits in 201 CRISPR screens.
DR BioGRID-ORCS; 100996331; 6 hits in 564 CRISPR screens.
DR Pharos; H3BUK9; Tdark.
DR PRO; PR:H3BUK9; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; H3BUK9; protein.
DR Bgee; ENSG00000230031; Expressed in testis and 5 other tissues.
DR Genevisible; H3BUK9; HS.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 3: Inferred from homology;
KW ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..544
FT /note="POTE ankyrin domain family member B2"
FT /id="PRO_0000423303"
FT REPEAT 135..167
FT /note="ANK 1"
FT REPEAT 168..200
FT /note="ANK 2"
FT REPEAT 201..233
FT /note="ANK 3"
FT REPEAT 234..266
FT /note="ANK 4"
FT REPEAT 267..299
FT /note="ANK 5"
FT REGION 332..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 61708 MW; 0F75ABBB59531FB9 CRC64;
MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGT SNVGTSGDHD DSFMKTLRSK
MGKWCCHCFP CCRGSGKSNV GTWGDYDDSA FMEPRYHVRR EDLDKLHRAA WWGKVPRKDL
IVMLRDTDMN KRDKQKRTAL HLASANGNSE VVQLLLDRRC QLNVLDNKKR TALIKAVQCQ
EDECVLMLLE HGADGNIQDE YGNTALHYAI YNEDKLMAKA LLLYGADIES KNKCGLTPLL
LGVHEQKQEV VKFLIKKKAN LNALDRYGRT ALILAVCCGS ASIVNLLLEQ NVDVSSQDLS
GQTAREYAVS SHHHVICELL SDYKEKQMLK ISSENSNPEQ DLKLTSEEES QRLKVSENSQ
PEKMSQEPEI NKDCDREVEE EIKKHGSNPV GLPENLTNGA SAGNGDDGLI PQRKSRKPEN
QQFPDTENEE YHSDEQNDTQ KQLSEEQNTG ISQDEILTNK QKQIEVAEKE MNSELSLSHK
KEEDLLRENS MLREEIAKLR LELDETKHQN QLRENKILEE IESVKEKLLK TIQLNEEALT
KTSI
