POTB3_HUMAN
ID POTB3_HUMAN Reviewed; 581 AA.
AC A0JP26; A0A096LPD0; Q6NXN7; Q6S5H4; Q6S5H7;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 04-MAR-2015, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=POTE ankyrin domain family member B3 {ECO:0000312|HGNC:HGNC:51240};
GN Name=POTEB3 {ECO:0000312|HGNC:HGNC:51240};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000312|EMBL:AAI27124.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), AND VARIANTS ASP-30; VAL-43
RP AND ASP-88.
RC TISSUE=Prostate;
RX PubMed=15276201; DOI=10.1016/j.gene.2004.05.009;
RA Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.;
RT "Five POTE paralogs and their splice variants are expressed in human
RT prostate and encode proteins of different lengths.";
RL Gene 337:45-53(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP GLY-203; GLU-286; GLU-511; LYS-535 AND THR-568.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A0JP26; Q08AG9: CYP21A2; NbExp=3; IntAct=EBI-18165900, EBI-14156412;
CC A0JP26; O95995: GAS8; NbExp=3; IntAct=EBI-18165900, EBI-1052570;
CC A0JP26; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-18165900, EBI-10302392;
CC A0JP26; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-18165900, EBI-11993254;
CC A0JP26; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-18165900, EBI-3958099;
CC A0JP26; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-18165900, EBI-1044640;
CC A0JP26; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-18165900, EBI-2683507;
CC A0JP26; Q5T6S3: PHF19; NbExp=3; IntAct=EBI-18165900, EBI-2339674;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A0JP26-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0JP26-2; Sequence=VSP_059381, VSP_059382;
CC Name=3;
CC IsoId=A0JP26-3; Sequence=VSP_059380;
CC -!- SIMILARITY: Belongs to the POTE family. {ECO:0000305}.
CC -!- CAUTION: Maps to a duplicated region on chromosome 15; the gene is
CC present in at least 3 almost identical copies. {ECO:0000305}.
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DR EMBL; AY465170; AAS58869.1; -; mRNA.
DR EMBL; AY465173; AAS58872.1; -; mRNA.
DR EMBL; AC060814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066981; AAH66981.1; -; mRNA.
DR EMBL; BC127123; AAI27124.1; -; mRNA.
DR CCDS; CCDS73690.1; -. [A0JP26-1]
DR RefSeq; NP_997238.2; NM_207355.3. [A0JP26-1]
DR RefSeq; XP_011542097.1; XM_011543795.2. [A0JP26-2]
DR AlphaFoldDB; A0JP26; -.
DR SMR; A0JP26; -.
DR BioGRID; 130821; 34.
DR IntAct; A0JP26; 34.
DR STRING; 9606.ENSP00000483103; -.
DR iPTMnet; A0JP26; -.
DR PhosphoSitePlus; A0JP26; -.
DR BioMuta; POTEB; -.
DR BioMuta; POTEB3; -.
DR DMDM; 55976443; -.
DR jPOST; A0JP26; -.
DR MassIVE; A0JP26; -.
DR PeptideAtlas; A0JP26; -.
DR PRIDE; A0JP26; -.
DR ProteomicsDB; 67336; -.
DR ProteomicsDB; 67337; -.
DR ProteomicsDB; 67338; -.
DR Antibodypedia; 74724; 78 antibodies from 14 providers.
DR Ensembl; ENST00000611217.5; ENSP00000483103.1; ENSG00000278522.5. [A0JP26-1]
DR Ensembl; ENST00000612601.2; ENSP00000483189.1; ENSG00000278522.5. [A0JP26-2]
DR GeneID; 102724631; -.
DR KEGG; hsa:102724631; -.
DR MANE-Select; ENST00000611217.5; ENSP00000483103.1; NM_207355.5; NP_997238.2.
DR UCSC; uc059gqe.1; human.
DR CTD; 102724631; -.
DR GeneCards; POTEB3; -.
DR HGNC; HGNC:51240; POTEB3.
DR HPA; ENSG00000278522; Tissue enriched (testis).
DR neXtProt; NX_A0JP26; -.
DR PharmGKB; PA164724702; -.
DR VEuPathDB; HostDB:ENSG00000278522; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000163068; -.
DR OMA; LILNCWA; -.
DR OrthoDB; 397907at2759; -.
DR PhylomeDB; A0JP26; -.
DR PathwayCommons; A0JP26; -.
DR SignaLink; A0JP26; -.
DR BioGRID-ORCS; 102724631; 7 hits in 103 CRISPR screens.
DR ChiTaRS; POTEB3; human.
DR GenomeRNAi; 102724631; -.
DR Pharos; A0JP26; Tdark.
DR PRO; PR:A0JP26; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; A0JP26; protein.
DR Bgee; ENSG00000278522; Expressed in testis and 15 other tissues.
DR ExpressionAtlas; A0JP26; baseline and differential.
DR Genevisible; A0JP26; HS.
DR Gene3D; 1.25.40.20; -; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..581
FT /note="POTE ankyrin domain family member B3"
FT /id="PRO_0000432398"
FT REPEAT 172..201
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 205..234
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REPEAT 238..267
FT /note="ANK 3"
FT /evidence="ECO:0000255"
FT REPEAT 271..300
FT /note="ANK 4"
FT /evidence="ECO:0000255"
FT REPEAT 304..333
FT /note="ANK 5"
FT /evidence="ECO:0000255"
FT REPEAT 337..366
FT /note="ANK 6"
FT /evidence="ECO:0000255"
FT REGION 369..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 489..577
FT /evidence="ECO:0000255"
FT COMPBIAS 378..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 42..78
FT /note="Missing (in isoform 3)"
FT /id="VSP_059380"
FT VAR_SEQ 376..381
FT /note="EQDLKL -> GKEAEE (in isoform 2)"
FT /id="VSP_059381"
FT VAR_SEQ 382..581
FT /note="Missing (in isoform 2)"
FT /id="VSP_059382"
FT VARIANT 30
FT /note="H -> D (in dbSNP:rs200845208)"
FT /evidence="ECO:0000269|PubMed:15276201"
FT /id="VAR_080181"
FT VARIANT 43
FT /note="M -> V (in dbSNP:rs2605913)"
FT /id="VAR_019915"
FT VARIANT 88
FT /note="N -> D (in dbSNP:rs2458862)"
FT /evidence="ECO:0000269|PubMed:15276201"
FT /id="VAR_019919"
FT VARIANT 203
FT /note="D -> G"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_080182"
FT VARIANT 286
FT /note="Q -> E (in dbSNP:rs2445603)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_080183"
FT VARIANT 511
FT /note="K -> E (in dbSNP:rs1949282)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_019921"
FT VARIANT 535
FT /note="M -> K (in dbSNP:rs1828869)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_019922"
FT VARIANT 568
FT /note="A -> T (in dbSNP:rs1828868)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_059119"
FT CONFLICT 510
FT /note="S -> P (in Ref. 3; AAI27124)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 581 AA; 65710 MW; 86D1E88F98BD22DF CRC64;
MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD DSFMKTLRSK
MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK WCCHCFPCCR GSGKSNVGTW
GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KQKRTALHLA
SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DGNIQDEYGN
TALHYAIYNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA
LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY
KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK MSQEPEINKD CDREVEEEIK
KHGSNPVGLP ENLTNGASAG NGDDGLIPQR KSRKPENQQF PDTENEEYHS DEQNDTQKQL
SEEQNTGISQ DEILTNKQKQ IEVAEKEMNS KLSLSHKKEE DLLRENSMLR EEIAMLRLEL
DETKHQNQLR ENKILEEIES VKEKLLKAIQ LNEEALTKTS I
