POTB_HAEIN
ID POTB_HAEIN Reviewed; 286 AA.
AC P45170;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Spermidine/putrescine transport system permease protein PotB;
GN Name=potB; OrderedLocusNames=HI_1346;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Required for the activity of the bacterial periplasmic
CC transport system of putrescine and spermidine. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. CysTW subfamily. {ECO:0000305}.
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DR EMBL; L42023; AAC22990.1; -; Genomic_DNA.
DR PIR; A64118; A64118.
DR RefSeq; NP_439497.1; NC_000907.1.
DR RefSeq; WP_005694014.1; NC_000907.1.
DR AlphaFoldDB; P45170; -.
DR SMR; P45170; -.
DR STRING; 71421.HI_1346; -.
DR EnsemblBacteria; AAC22990; AAC22990; HI_1346.
DR KEGG; hin:HI_1346; -.
DR PATRIC; fig|71421.8.peg.1398; -.
DR eggNOG; COG1176; Bacteria.
DR HOGENOM; CLU_016047_18_3_6; -.
DR OMA; RIYAWMI; -.
DR PhylomeDB; P45170; -.
DR BioCyc; HINF71421:G1GJ1-1371-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..286
FT /note="Spermidine/putrescine transport system permease
FT protein PotB"
FT /id="PRO_0000060178"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..33
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 34..71
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..91
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 92..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 121..151
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..171
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 172..199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..219
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 220..252
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..272
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 273..286
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 66..274
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 286 AA; 32210 MW; C8CC2F1A5866920B CRC64;
MKIINNKFQK ITVAIIFSWL IFFVLIPNLL VLAVSFLTRD GSNFYAFPIT IENYTNLFNP
LYAQVVWNSL SMSGIATIIC LLIGYPFAFM MSKIHPKYRP LLLFLVVLPF WTNSLIRIYG
MKVFLGVKGI LNTMLIDMGI LSAPIRILNT EIAVIIGLVY LLLPFMILPL YSAIEKLDNR
LLEAARDLGA NTFQRFFRVI LPLTMPGIIA GCLLVLLPAM GMFYVADLLG GAKVLLVGNV
IKSEFLISRN WPFGSAVSIG LTVLMALLIF VYYRANKLLN RKVELE
