ID   POTE1_MACFA             Reviewed;         634 AA.
AC   Q95K48;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Protection of telomeres protein 1;
DE   AltName: Full=POT1-like telomere end-binding protein;
GN   Name=POT1; ORFNames=QtrA-10940;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the telomerase ribonucleoprotein (RNP) complex
CC       that is essential for the replication of chromosome termini. Is a
CC       component of the double-stranded telomeric DNA-binding TRF1 complex
CC       which is involved in the regulation of telomere length by cis-
CC       inhibition of telomerase. Also acts as a single-stranded telomeric DNA-
CC       binding protein and thus may act as a downstream effector of the TRF1
CC       complex and may transduce information about telomere maintenance and/or
CC       length to the telomere terminus. Component of the shelterin complex
CC       (telosome) that is involved in the regulation of telomere length and
CC       protection. Shelterin associates with arrays of double-stranded TTAGGG
CC       repeats added by telomerase and protects chromosome ends; without its
CC       protective activity, telomeres are no longer hidden from the DNA damage
CC       surveillance and chromosome ends are inappropriately processed by DNA
CC       repair pathways. Binds to two or more telomeric single-stranded 5'-
CC       TTAGGG-3' repeats (G-strand) and with high specificity to a minimal
CC       telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric
CC       single-stranded sequences internally or at proximity of a 3'-end. Its
CC       activity is TERT dependent but it does not increase TERT activity by
CC       itself. In contrast, the ACD-POT1 heterodimer enhances telomere
CC       elongation by increasing telomerase processivity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer or homooligomer. Component of the shelterin complex
CC       (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1.
CC       Binds single-stranded telomeric DNA as a monomer. Associated component
CC       of the telomerase holoenzyme complex. Found in a complex with TERF1,
CC       TINF2 and TNKS1. Interacts with TNKS1. Forms heterodimers with ACD.
CC       Identified in a complex with ACD and single-stranded telomeric DNA.
CC       {ECO:0000250|UniProtKB:Q9NUX5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}. Note=Colocalizes with telomeric DNA. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the telombin family. {ECO:0000305}.
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DR   EMBL; AB066545; BAB62219.1; -; mRNA.
DR   RefSeq; NP_001306488.1; NM_001319559.1.
DR   AlphaFoldDB; Q95K48; -.
DR   SMR; Q95K48; -.
DR   STRING; 9541.XP_005550714.1; -.
DR   GeneID; 102125077; -.
DR   CTD; 25913; -.
DR   eggNOG; KOG4757; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; ISS:UniProtKB.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; ISS:UniProtKB.
DR   Gene3D; 2.40.50.140; -; 2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR028389; POT1.
DR   InterPro; IPR032042; POT1PC.
DR   InterPro; IPR011564; Telomer_end-bd_POT1/Cdc13.
DR   PANTHER; PTHR14513; PTHR14513; 1.
DR   Pfam; PF02765; POT1; 1.
DR   Pfam; PF16686; POT1PC; 1.
DR   SMART; SM00976; Telo_bind; 1.
DR   SUPFAM; SSF50249; SSF50249; 2.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA-binding; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..634
FT                   /note="Protection of telomeres protein 1"
FT                   /id="PRO_0000121729"
SQ   SEQUENCE   634 AA;  71524 MW;  C168425E0073121C CRC64;
     MSLVPATNYI YTPLNQLKGG TIVNVYGVVK FFKPPYLSKG TDYCSVVTIV DQTNVKLTCL
     LFSGNYEALP IIYKNGDIVR FHRLKIQVYK KETQGITSSG FASLTFEGTL GAPIIPRTSS
     KYFNFTTEDH KMVETLRVWA STHMSPSWTL LKLCDVQPMQ YFDLTCQLLG KAEVDGASFL
     LKVWDGTRTP FPSWRVLIQD LVLEGDLSHI HRLQNLTIDI LVYDNHVHVA RSLKVGSFLR
     IYSLHTKLQS MNSENQTMLS LEFHLHGGTS YGRGIRVLPE TNSDVDQLKK DLESANLTAN
     HHSDVICQSE PDDSFPSSGS VSLYEVERCQ QLSATILTDH QYLERTPLCA ILKQKAPQQY
     RIRAKLRSYK PRRLFQSVKL HCPKCHLLQE VPREGDLDII LQDGATKTPD VKLQNTALYD
     SKIWTTKNQK GRKVAVHFVK NNGILPLSNE CLLLIEGGTL SEICKLSNKF NSVIPVRSGH
     EDLELLDLSA PFLIQGTIHH YGCKQCSSLR SIQNLNSLVD KTSWIPSSVA EVLGIVPLQY
     VFVMTFTLDD GTGVLEAYLM DSDKFFQIPA SEVLMDDDLQ KSMDMIMDMF CPPGIKIDAY
     PWLECFIKSY NVTNGTDNQI CYQIFDTTVA EDVI