POTEA_HUMAN
ID POTEA_HUMAN Reviewed; 498 AA.
AC Q6S8J7; A6ND17; A6ND71; Q6S8J6;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=POTE ankyrin domain family member A;
DE AltName: Full=ANKRD26-like family A member 1;
DE AltName: Full=Prostate, ovary, testis-expressed protein on chromosome 8;
DE Short=POTE-8;
GN Name=POTEA; Synonyms=A26A1, POTE8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Prostate;
RX PubMed=15276201; DOI=10.1016/j.gene.2004.05.009;
RA Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.;
RT "Five POTE paralogs and their splice variants are expressed in human
RT prostate and encode proteins of different lengths.";
RL Gene 337:45-53(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=A;
CC IsoId=Q6S8J7-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=Q6S8J7-2; Sequence=VSP_011974;
CC -!- SIMILARITY: Belongs to the POTE family. {ECO:0000305}.
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DR EMBL; AY462869; AAS58863.1; -; mRNA.
DR EMBL; AY462870; AAS58864.1; -; mRNA.
DR EMBL; AC022616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001002920.1; NM_001002920.1. [Q6S8J7-2]
DR RefSeq; NP_001005365.2; NM_001005365.2. [Q6S8J7-1]
DR AlphaFoldDB; Q6S8J7; -.
DR SMR; Q6S8J7; -.
DR BioGRID; 131050; 5.
DR IntAct; Q6S8J7; 1.
DR iPTMnet; Q6S8J7; -.
DR PhosphoSitePlus; Q6S8J7; -.
DR BioMuta; POTEA; -.
DR DMDM; 55976446; -.
DR jPOST; Q6S8J7; -.
DR MassIVE; Q6S8J7; -.
DR MaxQB; Q6S8J7; -.
DR PeptideAtlas; Q6S8J7; -.
DR PRIDE; Q6S8J7; -.
DR ProteomicsDB; 67350; -. [Q6S8J7-1]
DR ProteomicsDB; 67351; -. [Q6S8J7-2]
DR DNASU; 340441; -.
DR GeneID; 340441; -.
DR KEGG; hsa:340441; -.
DR CTD; 340441; -.
DR DisGeNET; 340441; -.
DR GeneCards; POTEA; -.
DR HGNC; HGNC:33893; POTEA.
DR MIM; 608915; gene.
DR neXtProt; NX_Q6S8J7; -.
DR PharmGKB; PA164724701; -.
DR InParanoid; Q6S8J7; -.
DR OrthoDB; 380630at2759; -.
DR PhylomeDB; Q6S8J7; -.
DR PathwayCommons; Q6S8J7; -.
DR SignaLink; Q6S8J7; -.
DR BioGRID-ORCS; 340441; 2 hits in 132 CRISPR screens.
DR GenomeRNAi; 340441; -.
DR Pharos; Q6S8J7; Tdark.
DR PRO; PR:Q6S8J7; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6S8J7; protein.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..498
FT /note="POTE ankyrin domain family member A"
FT /id="PRO_0000066915"
FT REPEAT 98..127
FT /note="ANK 1"
FT REPEAT 131..160
FT /note="ANK 2"
FT REPEAT 164..193
FT /note="ANK 3"
FT REPEAT 197..226
FT /note="ANK 4"
FT REPEAT 230..259
FT /note="ANK 5"
FT REGION 289..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 469..497
FT /evidence="ECO:0000255"
FT COMPBIAS 289..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 233..278
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15276201"
FT /id="VSP_011974"
SQ SEQUENCE 498 AA; 56166 MW; 758C1C7BD6F10395 CRC64;
MVAEVSPKLA ASPMKKPFGF RGKMGKWCCC CFPCCRGSGK NNMGAWRDHD DSAFTEPRYH
VRREDLGKLH RAAWWGEVPR ADLIVMLRGP GINKRDKKKR TALHLACANG NSEVVSLLLD
RQCQLHVFDS KKRTALIKAV QCQEDECALM LLQHGTDPNL PDMYGNTALH YAVYNEDKLM
AKTLLLYGAD IESKNKGGLT PLLLAVHGQK QRMVKFLIKK KANLNALDRF GRTALILAVR
CGSASIVSLL LQQNIDVFSQ DVFGQTAEDY AVSSHHSIIC QLLSDYKENQ MPNNSSGNSN
PEQDLKLTSE EEPQRLKGSE NSQHEKVTQE PDINKDCDRE VEEEMQKHGS NNVGLSENLT
DGAAAGNGDG GLVPQRKSRK HENQQFPNTE IEEYHRPEKK SNEKNKVKSQ IHSVDNLDDI
TWPSEIASED YDLLFSNYET FTLLIEQLKM DFNDSASLSK IQDAVISEEH LLELKNSHYE
QLTVEVEQME NMVHVLQK
