POTEC_HUMAN
ID POTEC_HUMAN Reviewed; 542 AA.
AC B2RU33;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=POTE ankyrin domain family member C;
DE AltName: Full=ANKRD26-like family B member 2;
DE AltName: Full=Prostate, ovary, testis-expressed protein on chromosome 18;
DE Short=POTE-18;
GN Name=POTEC; Synonyms=A26B2, POTE18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-375, AND VARIANTS ALA-3 AND
RP ASP-86.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=12475935; DOI=10.1073/pnas.262655399;
RA Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V.,
RA Lee B., Pastan I.;
RT "POTE, a highly homologous gene family located on numerous chromosomes and
RT expressed in prostate, ovary, testis, placenta, and prostate cancer.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16975-16980(2002).
RN [4]
RP ERRATUM OF PUBMED:12475935.
RA Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V.,
RA Lee B., Pastan I.;
RL Proc. Natl. Acad. Sci. U.S.A. 100:1462-1462(2003).
CC -!- TISSUE SPECIFICITY: Expressed in prostate and testis.
CC {ECO:0000269|PubMed:12475935}.
CC -!- SIMILARITY: Belongs to the POTE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI40941.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AP006261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140940; AAI40941.1; ALT_SEQ; mRNA.
DR CCDS; CCDS45835.1; -.
DR RefSeq; NP_001131143.1; NM_001137671.1.
DR AlphaFoldDB; B2RU33; -.
DR SMR; B2RU33; -.
DR BioGRID; 132700; 12.
DR IntAct; B2RU33; 9.
DR STRING; 9606.ENSP00000351856; -.
DR iPTMnet; B2RU33; -.
DR PhosphoSitePlus; B2RU33; -.
DR BioMuta; POTEC; -.
DR MassIVE; B2RU33; -.
DR MaxQB; B2RU33; -.
DR PaxDb; B2RU33; -.
DR PeptideAtlas; B2RU33; -.
DR PRIDE; B2RU33; -.
DR ProteomicsDB; 3455; -.
DR Antibodypedia; 81840; 1 antibodies from 1 providers.
DR DNASU; 388468; -.
DR Ensembl; ENST00000358970.10; ENSP00000351856.5; ENSG00000183206.18.
DR GeneID; 388468; -.
DR KEGG; hsa:388468; -.
DR MANE-Select; ENST00000358970.10; ENSP00000351856.5; NM_001137671.2; NP_001131143.1.
DR UCSC; uc010dln.4; human.
DR CTD; 388468; -.
DR GeneCards; POTEC; -.
DR HGNC; HGNC:33894; POTEC.
DR HPA; ENSG00000183206; Tissue enriched (testis).
DR neXtProt; NX_B2RU33; -.
DR OpenTargets; ENSG00000183206; -.
DR PharmGKB; PA164724729; -.
DR VEuPathDB; HostDB:ENSG00000183206; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000163068; -.
DR HOGENOM; CLU_000134_9_2_1; -.
DR InParanoid; B2RU33; -.
DR OMA; ANVIPRM; -.
DR OrthoDB; 1514637at2759; -.
DR PhylomeDB; B2RU33; -.
DR TreeFam; TF337879; -.
DR PathwayCommons; B2RU33; -.
DR SignaLink; B2RU33; -.
DR BioGRID-ORCS; 388468; 32 hits in 998 CRISPR screens.
DR ChiTaRS; POTEC; human.
DR GenomeRNAi; 388468; -.
DR Pharos; B2RU33; Tdark.
DR PRO; PR:B2RU33; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; B2RU33; protein.
DR Bgee; ENSG00000183206; Expressed in testis and 38 other tissues.
DR ExpressionAtlas; B2RU33; baseline and differential.
DR Genevisible; B2RU33; HS.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 2: Evidence at transcript level;
KW ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..542
FT /note="POTE ankyrin domain family member C"
FT /id="PRO_0000345419"
FT REPEAT 138..171
FT /note="ANK 1"
FT REPEAT 172..201
FT /note="ANK 2"
FT REPEAT 205..234
FT /note="ANK 3"
FT REPEAT 238..267
FT /note="ANK 4"
FT REPEAT 271..300
FT /note="ANK 5"
FT REPEAT 304..333
FT /note="ANK 6"
FT REPEAT 337..373
FT /note="ANK 7"
FT REGION 369..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 489..538
FT /evidence="ECO:0000255"
FT COMPBIAS 378..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 3
FT /note="T -> A (in dbSNP:rs28535987)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_045825"
FT VARIANT 10
FT /note="A -> T (in dbSNP:rs45488295)"
FT /id="VAR_045826"
FT VARIANT 13
FT /note="A -> T (in dbSNP:rs45561536)"
FT /id="VAR_045827"
FT VARIANT 28
FT /note="F -> C (in dbSNP:rs45626231)"
FT /id="VAR_045828"
FT VARIANT 30
FT /note="H -> P (in dbSNP:rs9807633)"
FT /id="VAR_045829"
FT VARIANT 36
FT /note="K -> R (in dbSNP:rs45570841)"
FT /id="VAR_045830"
FT VARIANT 66
FT /note="H -> R (in dbSNP:rs9807555)"
FT /id="VAR_045831"
FT VARIANT 72
FT /note="C -> Y (in dbSNP:rs45554841)"
FT /id="VAR_045832"
FT VARIANT 86
FT /note="H -> D (in dbSNP:rs45469098)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_045833"
FT VARIANT 166
FT /note="M -> I (in dbSNP:rs12454500)"
FT /id="VAR_045834"
FT VARIANT 221
FT /note="C -> R (in dbSNP:rs7505568)"
FT /id="VAR_045835"
FT CONFLICT 337
FT /note="S -> C (in Ref. 2; AAI40941)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 542 AA; 61188 MW; E0268580D8A7F86E CRC64;
MVTEVCSMPA ASAVKKPFDL RSKMGKWFHH RFPCCKGSGK SNMGTSGDHD DSFMKMLRSK
MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK WCCHCFPCCR GSGKSNVGAW
GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KQKRTALHLA
SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DQNIPDEYGN
TTLHYAVHNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA
LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY
KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK MSQEPEINKD CDREVEEEIK
KHGSNPVGLP ENLTNGASAG NGDDGLIPQR RSRKPENQQF PDTENEEYHS DEQNDTRKQL
SEEQNTGISQ DEILTNKQKQ IEVAEKKMNS ELSLSHKKEE DLLRENSMLQ EEIAMLISGD
WN
